Altreno is the only topical tretinoin acne formulation that is a lotion.

Altreno (tretinoin 0.05%) from Ortho Dermatologics is first tretinoin lotion approved for use in acne and is used in patients 9 years of age and older. Other topical tretinoin products for acne are available, but do not come as a lotion; these include: Atralin (gel), Avita (cream and gel), Retin-A (cream and gel), and Retin-A Micro (gel).

Tretinoin is an effective topical retinoid commonly used to treat acne, but retinoids can be associated with skin dryness, peeling, and sensitivity. Altreno lotion includes hyaluronic acid, glycerin and collagen with moisturizing effects. Skin dryness, pain, swelling, irritation and peeling were reported in ≤4% of patients with Altreno.