Daxxify (daxibotulinumtoxinA-lanm) is the first Botox alternative that is free of human albumin or animal-based components, and it was FDA-approved in September 2022. It is also the longest-lasting of all the cosmetic injectable wrinkle treatments, lasting for 6 months in most people and 9 months in some. Daxxify is made by Revance Therapeutics Inc., and the formulation uses a patented, innovative, cell-penetrating peptide technology (called Peptide Exchange Technology) consisting of a man-made 35-amino acid stabilizing excipient with a highly positive charge.

How often does Daxxify need to be injected?

Daxxify only needs two treatments a year to give year-long results, because the average duration of effect is six months. In some people, Daxxify lasts for 9 months. Botox only lasts for 3 to 4 months.

Clinical trials reported 80 percent of people using Daxxify had no or minimally visible facial wrinkles after four months, with approximately 50% with little evidence of wrinkles at six months.

What is Daxxify FDA-approved for?

Currently, Daxxify is only FDA-approved to treat glabella lines – the short vertical skin lines that appear between the eyebrows and above the nose. These are usually the first wrinkles to appear on the forehead.

What is the recommended dosage for Daxxify?

Daxxify is usually given as 5 equal intramuscular injections of 8 units each (two injections into each corrugator muscle and one into the procerus muscle) for a total recommended dose of 40 units.

What does Daxxify cost?

Because Daxxify lasts longer it is likely to cost around 50% more than what you are currently paying for Botox, depending on your provider and where you are located. So if your current cost for a Botox treatment sits between $300 and $600, expect to pay around $450 to $900 for Daxxify treatment.

When is Daxxify likely to be available?

Most providers won’t be able to offer Daxxify until around March 2023, once education and training programs have been completed.