By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Medical Answers > What is the success rate of Cabometyx (cabozantinib)?

What is the success rate of Cabometyx (cabozantinib)?

Answers by TheMediTary.Com - Last updated: 12-Jul-2023

Cabometyx (cabozantinib) is a tyrosine kinase inhibitor used to treat certain patients with advanced renal cell carcinoma, hepatocellular (liver) cancer, or advanced or metastatic differentiated thyroid cancer.

It is a chemotherapy drug that you take until your cancer starts to get worse - disease progression - or you can no longer tolerate the drug because of side effects or adverse reactions.

How successful Cabometyx is can be measured by how long patients take the treatment for, how long they survive for without their cancer getting worse (progression-free survival), how many months they remain alive for while taking the treatment and how many patients respond to the drug.

How effective is Cabometyx?

Trial Duration of treatment Median progression-free survival (PFS), overall survival (OS) and overall response rate (ORR)
METEOR - advanced renal cell carcinoma Cabometyx: 7.6 months (range 0.3 - 20.5)
vs
Everolimus (Afinitor): 4.4 months (range 0.21 - 18.9)
PFS
Cabometyx: 7.4 months (95% CI 5.6, 9.1)
vs
Everolimus: 3.8 months (95% CI 3.7, 5.4)

OS
Cabometyx: 21.4 months (95% CI 18.7, NE)
vs
Everolimus: 16.5 months (95% CI 14.7, 18.8)

ORR
Partial responses only
Cabometyx: 17% (95% CI 13%, 22%)
vs
Everolimus: 3% (95% CI 2%, 6%)
CABOSUN - advance renal cell carcinoma Cabometyx: 6.5 months (range 0.2 - 28.7)
vs
Sunitinib (Sutent): 3.1 months (range 0.2 - 25.5)
PFS
Cabometyx: 8.6 months (95% CI 6.8, 14.0)
vs
Everolimus: 5.3 months (95% CI 3.0, 8.2)

ORR
Partial responses only
Cabometyx: 20% (95% CI 12%, 30.8%)
vs
Everolimus: 9% (95% CI 3.7%, 17.6%)

CHECKMATE-9ER - advanced renal cell carcinoma, first-line treatment Cabometyx plus nivolumab (Opdivo): 14 months (range 0.2 - 27) PFS
Cabometyx: 16.6 months (95% CI 12.5, 24.9)
vs
Sunitinib: 8.3 months (95% CI 7.0, 9.7)

OS
Cabometyx: Not reached
vs
Sunitinib: Not reached

ORR
Complete and partial responses
Cabometyx: 55.7% (95% CI 50.1, 61.2)
vs
Sunitinib: 27.1% (95% CI 22.4, 32.3)
CELESTIAL - advanced hepatocellular carcinoma Cabometyx: 3.8 months (range 0.1 - 37.3)
vs
Placeo: 2.0 months (range 0.0 - 27.2)
PFS
Cabometyx: 5.2 months (95% CI 4.0, 5.5)
vs
Placebo: 1.9 months (95% CI 1.9, 1.9)

OS
Cabometyx: 10.2 months (9.1, 12.0)
vs
Placebo: 8.0 months (6.8, 9.4)

ORR
Partial responses only
Cabometyx: 4% (95% CI2.3, 6.0)
vs
Placebo: 0.4% (95% CI 0.0, 2.3)
COSMIC-311 - radioiodine-refractory differentiated thyroid cancer previously treated with VEGFR-targeted therapy PFS (updated analysis)
Cabometyx: 11 months (95% CI 7.4, 13.8)
vs
Placebo: 1.9 months (95% CI 1.9, 3.7)

ORR (updated analysis)
Partial responses only
Cabometyx: 18% (95% CI 10%, 29%)
vs
Placebo: 0.0% (95% CI 0.0%, 11%)

Share this Article

Featured questions

  • What is the difference between Cabometyx and Cometriq?
  • How does Cabometyx work?
  • Cabometyx - My husband is having peeling off his testicles. Very red and hurting.
  • Is Cabometyx a chemotherapy drug?
  • How long do you take Cabometyx for?
  • Does Cabometyx (cabozantinib) cure cancer?
  • Can these drugs be used in Thalassemia patients?
  • How does Lupron (leuprolide) work for prostate cancer?
  • What is the consideration to use nifidepine over amlodipine?
  • Hypertrophic cardiomyopathy/mechanical heart valve?
  • I have been on 400mg of tramadol a day for 20 years, decided its time to come off them
  • Cetirizine - can cetirizine be taken for long periods of time?
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch (Hydrocortisone topical)
Centrum Adult (Multivitamins and minerals)
Crovalimab
Cyltezo Prefilled Syringe (Adalimumab)
Zepbound Pen (Tirzepatide)
Mylanta One (Calcium carbonate, magnesium hydroxide, and simethicone)
Uretron Ds (Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate)
Medihoney Wound And Burn Dressing (Topical emollients)
Lidotrode
Libervant (Diazepam (buccal))
Moderna Covid-19 (Covid-19 (6m-11y) vaccine, moderna (2024-2025))
Beqvez (Fidanacogene elaparvovec)
Beqvez (Fidanacogene elaparvovec)
Beqvez (Fidanacogene elaparvovec)

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by