By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Medical Answers > Why give Taxol (Paxel) before carboplatin?

Why give Taxol (Paxel) before carboplatin?

Answers by TheMediTary.Com - Last updated: 13-Jul-2023

Taxol (paclitaxel, Paxel) must be given before carboplatin because if carboplatin is given before Taxol, it stops Taxol from having an effect on cancer cells. This is called a scheduling interaction because when Taxol is given before carboplatin, there is little interaction and both agents work as intended.

The combination of carboplatin and paclitaxel is widely used to treat multiple solid tumors including ovarian, lung, and breast cancer. Research has shown that the pretreatment or simultaneous treatment with carboplatin inhibited Taxol-induced I-kappa, B-alpha degradation, and BCL-2 phosphorylation. Further analyses demonstrated that carboplatin could significantly interfere with the cytotoxic effects of Taxol on both mitotic arrest and apoptotic cell death unless Taxol was administered before carboplatin. These results indicate that the interaction between paclitaxel and carboplatin is highly schedule-dependent and the optimal schedule is Taxol (paclitaxel, Paxel) followed by carboplatin.

Why is Taxol and carboplatin used together?

A landmark study in 1996 showed that Taxol and carboplatin in combination was better for the treatment of advanced ovarian cancer because it was less toxic than the combination used at the time, Taxol and cisplatin. Carboplatin-Taxol in combination were also just as effective as cisplatin-Taxol. Carboplatin-Taxol have been a standard chemotherapy combination used for more than 25 years for the treatment of ovarian cancer. The combination is also used to treat many other solid tumors.

How effective is Taxol and carboplatin?

The combination of carboplatin-Taxol is well tolerated and achieves a clinical response rate of 50% to 81% and an average progression free survival (PFS) of 13.6 to 19.3 months. Other findings include:

  • For patients with optimally debulked advanced ovarian cancer revealed the median PFS for carboplatin-Taxol was 20.7 months compared to 19.4 with cisplatin-Taxol
  • Overall survival was 57.4 months with carboplatin-Taxol compared to 48.7 months with cisplatin-Taxol
  • Gastrointestinal, renal, metabolic toxicity and leukopenia were significantly more in cisplatin-Taxol group compared with carboplatin-Taxol
  • Quality-of-life scores at the end of treatment were significantly better with carboplatin-Taxol (65.25) compared with cisplatin-Taxol (51.97).
  • Toxic side effects, such as nausea and weight loss, are less with carboplatin-Taxol
  • Carboplatin-Taxol can be administered safely and effectively over a 3-hour infusion period. Previously, cisplatin-Taxol was administered over 24 hours, requiring a hospital stay.
Share this Article

Featured questions

  • How long does it take for Paxil increase to kick in. And should I start with 5 mg increases?
  • Gabapentin - How bad is weight gain? Can diet help? How good for sleep and pain?
  • Anxiety - Has anyone been on Paxil for 20+ years? I've been taking it for 26 years & am unable to?
  • I have severe withdrawal symptoms after weening off Paxil after 10 years, what should I do?
  • Is there anything out there other than benzos that help with panic attacks and depression?
  • How long should I expect side effects of paxil to last?
  • Do antidepressants really lift your mood and improve anxiety help?
  • Has anyone taken paxil?
  • Has anyone experienced concentration, focusing, memory problems due to depression or anxiety?
  • Did anybody take paxil during pregnancy? Is this OK?
  • I have been on Paxil for 3 days. Made me very sick like I have the flu, anyone else have this?
  • Olanzapine - Olanza - tired/groggy/spaced out?
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch (Hydrocortisone topical)
Centrum Adult (Multivitamins and minerals)
Crovalimab
Cyltezo Prefilled Syringe (Adalimumab)
Zepbound Pen (Tirzepatide)
Mylanta One (Calcium carbonate, magnesium hydroxide, and simethicone)
Uretron Ds (Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate)
Medihoney Wound And Burn Dressing (Topical emollients)
Lidotrode
Libervant (Diazepam (buccal))
Moderna Covid-19 (Covid-19 (6m-11y) vaccine, moderna (2024-2025))
Beqvez (Fidanacogene elaparvovec)
Beqvez (Fidanacogene elaparvovec)
Beqvez (Fidanacogene elaparvovec)

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by