Applies to methyl aminolevulinate topical: topical cream.
Warning
You should not use this medicine if you are allergic to porphyrins, peanuts or almonds, or if your skin is especially sensitive to light.
Get emergency medical help if you have any of these signs of an allergic reaction while taking methyl aminolevulinate topical: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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severe stinging, burning, redness, oozing, or swelling of treated skin areas (especially if these effects get worse or last longer than 3 weeks).
Common side effects may include:
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skin redness, warmth, burning, stinging, or swelling;
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blisters, skin ulcers; or
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peeling or crusting of treated skin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to methyl aminolevulinate topical: topical cream.
Hypersensitivity
Postmarketing reports: Eczema, allergic contact dermatitis, urticaria, . Most cases were localized to the treatment area, but rarely, erythema and swelling have been more extensive. Contact sensitization has been demonstrated in dermal safety studies.[Ref]
Ocular
Very common (10% or more): Eyelid edema (18%):
Uncommon (0.1% to 1%): Eye swelling, eye pain, eye irritation
Postmarketing reports: Eyelid swelling, macular edema, vitreous detachment, keratitis[Ref]
Local
Very common (10% or more): Skin burning/pain/discomfort (86%; 20% severe), erythema (63%; 6% severe), scabbing/crusting/blister/erosions (29%; 2% severe), pruritus (22%), skin or eyelid edema (18%; 2% severe), skin exfoliation (14%; 3% severe)
Common (1% to 10%): Skin warmth (4%), application site discharge (2%), skin hemorrhage (2%), skin tightness (2%), and skin hyperpigmentation (2%)[Ref]
Other
Common (1% to 10%): Application site discharge, feeling hot
Uncommon (0.1% to 1%): Fatigue[Ref]
Nervous system
Common (1% to 10%): Paresthesia, headache
Uncommon (0.1% to 1%): Dizziness[Ref]
Cardiovascular
Frequency not reported: Hypertension[Ref]
Dermatologic
Very common (10% or more): Burning sensation of the skin (50%), erythema (46%), skin pain (21%), stinging (19%), crusting (15%), skin edema (15%), pruritus/itching (13%), skin peeling (11%), blisters (11%), scab
Common (1% to 10%): Skin bleeding, skin ulceration, skin infection
Uncommon (0.1% to 1%): Skin hyperpigmentation, urticaria, rash, skin irritation, photosensitivity reaction, skin hypopigmentation, skin hyperpigmentation, heat rash, skin discomfort, wound hemorrhage
Postmarketing reports: Angioedema[Ref]
