Summary
Commonly reported side effects of midodrine include: dysuria, paresthesia, pruritus, supine hypertension, and piloerection. Other side effects include: abdominal pain, pain, and chills. Continue reading for a comprehensive list of adverse effects.
Applies to midodrine: oral tablets.
Warning
- Possible marked supine hypertension; use recommended only in patients whose lives are considerably impaired despite standard care.22 Clinical benefits of therapy likely correspond with increases in 1-minute SBP (surrogate marker of therapeutic efficacy).22 However, clinical benefits of midodrine therapy (e.g., improved ability to carry out activities of daily living) not established.22 (See Orthostatic Hypotension under Uses.)
Side effects include:
Supine and sitting hypertension, paresthesias and pruritus (mainly of the scalp), goosebumps, chills, urinary urge, urinary retention, urinary frequency.
For Healthcare Professionals
Applies to midodrine: oral tablet.
General
The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.[Ref]
Cardiovascular
Common (1% to 10%): Supine hypertension, flushing
Uncommon (0.1% to 1%): Reflex bradycardia
Rare (less than 0.1%): Tachycardia, palpitations
Frequency not reported: Vasodilation/flushing face[Ref]
Nervous system
Very common (10% or more): Paresthesia (18.3%)
Common (1% to 10%): Headache
Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence[Ref]
Dermatologic
Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)
Common (1% to 10%): Rash
Frequency not reported: Skin hyperesthesia, erythema multiforme, dry skin[Ref]
Genitourinary
Very common (10% or more): Dysuria (13.4%)
Frequency not reported: Impaired urination[Ref]
Gastrointestinal
Common (1% to 10%): Nausea, dyspepsia, stomatitis
Frequency not reported: Dry mouth, canker sore, pyrosis, gastrointestinal distress, flatulence, abdominal pain, vomiting, diarrhea[Ref]
Other
Common (1% to 10%): Chills, pain
Frequency not reported: Asthenia[Ref]
Psychiatric
Uncommon (0.1% to 1%): Sleep disorders, insomnia, restlessness, excitability, irritability
Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety[Ref]
Hepatic
Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes[Ref]
Musculoskeletal
Frequency not reported: Backache, leg cramps[Ref]
Ocular
Frequency not reported: Visual field defect[Ref]
