Applies to neratinib: oral tablet.
Serious side effects of Neratinib
Along with its needed effects, neratinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking neratinib:
More common
- Diarrhea
Less common
- Confusion
- decreased urination
- dizziness
- dry mouth
- fainting
- increase in heart rate
- lightheadedness
- rapid breathing
- sunken eyes
- thirst
- unusual tiredness or weakness
- wrinkled skin
Rare
- Bloody urine
- increased blood pressure
- increased thirst
- itching, pain, redness, swelling, tenderness, or warmth on the skin
- loss of appetite
- lower back or side pain
- nausea
- raised, firm, bright red patches of skin on the arm or leg
- stomach pain
- swelling of the face, fingers, or lower legs
- trouble breathing
- vomiting
- weight gain
Other side effects of Neratinib
Some side effects of neratinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Belching
- bladder pain
- bloody nose
- bloody or cloudy urine
- decreased appetite
- decreased weight
- difficult, burning, or painful urination
- discoloration of the fingernails or toenails
- dry skin
- frequent urge to urinate
- heartburn
- indigestion
- muscle spasms
- stomach discomfort, upset, or pain
- swelling or inflammation of the mouth
Less common
- Deep cracks, grooves, or lines in the skin
- dry mouth
For Healthcare Professionals
Applies to neratinib: oral tablet.
General
The most common adverse reactions (more than 5%) were diarrhea, nausea, abdominal pain, fatigue, vomiting, rash, stomatitis, decreased appetite, muscle spasms, dyspepsia, increased AST or ALT, nail disorder, dry skin, abdominal distention, decreased weight, and urinary tract infection.[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (95%), nausea (43%), abdominal pain (36%), vomiting (26%), stomatitis (14%), dyspepsia (10%)
Common (1% to 10%): Abdominal distention, dry mouth[Ref]
Other
Very common (10% or more): Fatigue (27%)[Ref]
Dermatologic
Very common (10% or more): Rash (18%)
Common (1% to 10%): Nail disorder, rash, skin fissures[Ref]
Metabolic
Very common (10% or more): Decreased appetite (12%)
Common (1% to 10%): Decreased weight, dehydration[Ref]
Musculoskeletal
Very common (10% or more): Muscle spasms (11%)[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection[Ref]
Hepatic
Common (1% to 10%): Increased ALT, increased AST[Ref]
Respiratory
Common (1% to 10%): Epistaxis[Ref]
Cardiovascular
Frequency not reported: Hypotension[Ref]
Renal
Frequency not reported: Renal failure[Ref]
