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Home > Drugs > Palovarotene (systemic) (monograph) > Palovarotene (systemic) (monograph) Side Effects
Drugs

Palovarotene Side Effects

Applies to palovarotene: oral capsule.

Oral route (Capsule)

Embryo-Fetal ToxicityPalovarotene is contraindicated in pregnancy. Palovarotene may cause fetal harm. Because of the risk of teratogenicity and to minimize fetal exposure, palovarotene is to be administered only if conditions for pregnancy prevention are met.Premature Epiphyseal ClosurePremature epiphyseal closure occurs in growing pediatric patients treated with Palovarotene, close monitoring is recommended

Serious side effects of Palovarotene

Along with its needed effects, palovarotene may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking palovarotene:

More common

  • Back pain
  • bone pain
  • dark urine
  • difficulty in moving
  • difficulty in swallowing
  • dry lips or skin
  • fast heartbeat
  • flushing, redness of the skin
  • headache
  • itching of the skin
  • joint pain
  • lack or loss of strength
  • lack or slowing of normal growth in children
  • loss of appetite
  • loss or thinning of the hair
  • muscle aches, cramps, pain, or stiffness
  • nausea or vomiting
  • stomach pain, severe
  • swelling of the face, throat, or tongue
  • swelling of the hands, ankles, feet, or lower legs
  • swollen joints
  • trouble breathing
  • unusual tiredness or weakness
  • unusually warm skin
  • yellow eyes or skin

Incidence not known

  • Bloating
  • chills
  • constipation
  • discouragement
  • fear, nervousness
  • feeling sad or empty
  • fever
  • indigestion
  • irritability
  • lack of appetite
  • loss of bone mineral density
  • loss of interest or pleasure
  • pain or swelling in the arms or legs without any injury
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • thoughts or attempts at killing oneself
  • trouble concentrating
  • trouble sleeping

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