Applies to paromomycin: oral capsule.
Serious side effects of Paromomycin
Along with its needed effects, paromomycin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Other side effects of Paromomycin
Some side effects of paromomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Abdominal or stomach cramps
- diarrhea
- nausea
For Healthcare Professionals
Applies to paromomycin: oral capsule.
Gastrointestinal
Frequency not reported: Nausea, abdominal cramps, diarrhea, gastrointestinal intolerance, vomiting, abdominal discomfort, pancreatitis, elevated serum amylase[Ref]
Nausea, abdominal cramps, and diarrhea have been reported with doses greater than 3 g/day.
A patient with AIDS developed pancreatitis after 5 days of therapy with this drug for cryptosporidiosis. Serum amylase declined progressively after this drug was discontinued but became elevated after reinstitution of therapy.[Ref]
Nervous system
Ototoxicity and sensorineural damage have been reported, usually in patients who also had hepatic disease.[Ref]
Frequency not reported: Ototoxicity, sensorineural damage, headache, vertigo[Ref]
Hepatic
Transient elevated AST (greater than 3 times the upper limit of normal [3 x ULN]) and ALT (greater than 3 x ULN) were reported in patients receiving an IM formulation during a clinical study.[Ref]
Frequency not reported: Elevated AST, elevated ALT[Ref]
Other
Pyrexia was reported in patients receiving an IM formulation during a clinical study.[Ref]
Frequency not reported: Pyrexia[Ref]
Local
Frequency not reported: Injection site pain, injection site swelling[Ref]
Injection site pain and swelling were reported in patients receiving an IM formulation during a clinical study.[Ref]
