Uses of Arestin:

• It is used to treat swelling of the tissue around the teeth (periodontitis). It is used with scaling and root planing.

What do I need to tell my doctor BEFORE I take Arestin?

• If you have an allergy to minocycline or any other part of Arestin (minocycline hydrochloride periodontal microspheres).
• If you are allergic to Arestin (minocycline hydrochloride periodontal microspheres); any part of Arestin (minocycline hydrochloride periodontal microspheres); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you are breast-feeding or plan to breast-feed.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Arestin (minocycline hydrochloride periodontal microspheres) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Arestin?

• Tell all of your health care providers that you take Arestin (minocycline hydrochloride periodontal microspheres). This includes your doctors, nurses, pharmacists, and dentists.
• Do not chew hard, crunchy, or sticky foods for 1 week after treatment. Do not touch the treated area.
• Do not brush or floss near the treated area for 10 days.
• You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
• This medicine may cause a change in tooth color to yellow-gray-brown in children younger than 8 years old. If this change of tooth color happens, it will not go away. Talk with the doctor.
• Most of the time, Arestin (minocycline hydrochloride periodontal microspheres) is not for use in children younger than 8 years old. However, there may be times when these children may need to take Arestin (minocycline hydrochloride periodontal microspheres). Talk with the doctor.
• This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking Arestin (minocycline hydrochloride periodontal microspheres), call your doctor right away.

How is this medicine (Arestin) best taken?

Use Arestin (minocycline hydrochloride periodontal microspheres) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• This medicine will be given to you by a doctor.

What do I do if I miss a dose?

• Call the doctor for an office visit.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• Not able to pass urine or change in how much urine is passed.
• Very bad pain, swelling, or bleeding where treated.
• Mouth irritation or mouth sores.
• Very bad headache.
• Fever.
• Feeling very tired or weak.
• Shortness of breath, a big weight gain, or swelling in the arms or legs.
• Swollen gland.
• Muscle pain or weakness.
• Joint pain or swelling.
• A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Arestin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Mouth soreness.
• Headache.
• Flu-like signs.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Arestin?

• If you need to store Arestin (minocycline hydrochloride periodontal microspheres) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Arestin (minocycline hydrochloride periodontal microspheres), please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.