Note: This document contains side effect information about famotidine. Some dosage forms listed on this page may not apply to the brand name Pepcid.

Applies to famotidine: oral for suspension, oral tablets, oral tablets for, parenteral injection, parenteral injection for iv infusion only.

Side effects include:

Headache, dizziness, constipation, diarrhea.

For Healthcare Professionals

Applies to famotidine: compounding powder, intravenous solution, oral powder for reconstitution, oral tablet, oral tablet chewable, oral tablet disintegrating.

General

The most commonly reported side effects include headache, dizziness, constipation, and diarrhea.^[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, diarrhea

Uncommon (0.1% to 1%): Nausea, vomiting, flatulence, dry mouth, abdominal discomfort or distension^[Ref]

Nervous system

Convulsions occurred in patients with renal dysfunction.^[Ref]

Common (1% to 10%): Headache, dizziness

Very rare (less than 0.01%): Paresthesia, somnolence, epileptic seizures, convulsion

Frequency not reported: Grand mal seizure, taste disorder^[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, pruritus

Rare (0.01% to 0.1%): Urticaria, angioneurotic edema

Very rare (less than 0.01%): Alopecia, severe skin reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, epidermal necrolysis

Frequency not reported: Acne, dry skin, flushing^[Ref]

Other

Uncommon (0.1% to 1%): Fatigue

Frequency not reported: Asthenia, fatigue, facial/orbital edema, tinnitus^[Ref]

Metabolic

Uncommon (0.1% to 1%): Loss of appetite

Frequency not reported: Anorexia^[Ref]

Hematologic

Rare (0.01% to 0.1%): Thrombocytopenia, leukopenia, agranulocytosis, pancytopenia

Frequency not reported: Neutropenia^[Ref]

Hepatic

Rare (0.01% to 0.1%): Intrahepatic cholestasis, jaundice, increased liver enzyme abnormalities (transaminases, gamma GT, alkaline phosphatase, bilirubin)

Frequency not reported: Cholestatic jaundice, hepatitis^[Ref]

Hypersensitivity

Rare (0.01% to 0.1%): Hypersensitivity reactions, anaphylaxis^[Ref]

Respiratory

Rare (0.01% to 0.1%): Bronchospasm

Frequency not reported: Interstitial pneumonia^[Ref]

Musculoskeletal

Rare (0.01% to 0.1%): Arthralgia

Very rare (less than 0.01%): Muscle cramps

Frequency not reported: Rhabdomyolysis, musculoskeletal pain^[Ref]

Psychiatric

When patients obtained follow-up, psychic disturbances were found to be reversible.^[Ref]

Very rare (less than 0.01%): Hallucinations, disorientation, confusion, anxiety, agitation, depression, reduced libido, insomnia

Frequency not reported: Psychic disturbances^[Ref]

Cardiovascular

QT interval prolongation occurred in patients with renal dysfunction.^[Ref]

Very rare (less than 0.01%): Chest tightness, prolonged QT interval

Frequency not reported: Arrhythmia, atrioventricular block, palpitation^[Ref]

Genitourinary

Very rare (less than 0.01%): Impotence^[Ref]

Ocular

Frequency not reported: Conjunctival injection^[Ref]

Endocrine

Frequency not reported: Gynecomastia^[Ref]