Note: This document contains side effect information about aspirin / oxycodone. Some dosage forms listed on this page may not apply to the brand name Percodan.
Applies to aspirin / oxycodone: oral tablet.
Warning
- This drug is a strong pain drug that can put you at risk for addiction, abuse, and misuse. Misuse or abuse of this drug can lead to overdose and death. Talk with your doctor.
- You will be watched closely to make sure you do not misuse, abuse, or become addicted to this drug.
- This drug may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.
- The chance of very bad and sometimes deadly breathing problems may be greater when you first start this drug or anytime your dose is raised.
- Even one dose of this drug may be deadly if it is taken by someone else or by accident, especially in children. If this drug is taken by someone else or by accident, get medical help right away.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Using this drug for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor.
- This drug has an opioid drug in it. Severe side effects have happened when opioid drugs were used with benzodiazepines or other drugs that may make you drowsy or slow your actions. This includes slow or troubled breathing and death. Benzodiazepines include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepines may be used to treat many health problems like anxiety, trouble sleeping, or seizures. If you have questions, talk with your doctor.
- Many drugs interact with this drug and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use this drug with all of your drugs.
- Do not take with alcohol or products that have alcohol. Unsafe and sometimes deadly effects may happen.
- Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
Serious side effects of Percodan
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high potassium levels like a heartbeat that does not feel normal; feeling confused; feeling weak, lightheaded, or dizzy; feeling like passing out; numbness or tingling; or shortness of breath.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Very bad dizziness or passing out.
- Severe constipation or stomach pain. These may be signs of a severe bowel problem.
- Noisy breathing.
- Ringing in ears.
- Hearing loss.
- Dark urine or yellow skin or eyes.
- Not able to pass urine or change in how much urine is passed.
- Mood changes.
- Seizures.
- Chest pain or pressure or a fast heartbeat.
- Feeling confused.
- A severe and sometimes deadly problem called serotonin syndrome may happen if you take this drug with certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; severe diarrhea, upset stomach, or throwing up; or severe headache.
Other side effects of Percodan
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Constipation.
- Feeling dizzy, sleepy, tired, or weak.
- Upset stomach or throwing up.
- Headache.
- Stomach pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
For Healthcare Professionals
Applies to aspirin/oxycodone: oral tablet.
General
The most commonly reported adverse events have included lightheadedness, dizziness, drowsiness, sedation, nausea, and vomiting.[Ref]
Gastrointestinal
Oxycodone-Aspirin:
Frequency not reported: Nausea, vomiting, constipation
Postmarketing reports: Hemorrhagic gastric/duodenal ulcer, gastric/peptic ulcer, dyspepsia, abdominal pain, diarrhea, eructation, dry mouth, gastrointestinal bleeding, intestinal perforation, pancreatitis, intestinal obstruction, ileus, thirst, aspiration
Aspirin:
Frequency not reported: Anorexia[Ref]
Nervous system
Frequency not reported: Lightheadedness, dizziness, drowsiness, sedation
Postmarketing reports: Stupor, paresthesia, cerebral edema, coma, subdural or intracranial hemorrhage, seizures
Opioids:
Postmarketing reports: Serotonin syndrome[Ref]
Renal
Postmarketing reports: Renal insufficiency and failure[Ref]
Hematologic
Oxycodone-aspirin:
Postmarketing reports: Unspecified hemorrhage, purpura, reticulocytosis, prolongation of prothrombin time, disseminated intravascular coagulation, ecchymosis, thrombocytopenia
Aspirin:
Frequency not reported: Leukopenia, thrombocytopenia, purpura, decreased iron concentration, shortened erythrocyte survival time[Ref]
Hypersensitivity
Postmarketing reports: Anaphylaxis, allergic reaction, angioedema[Ref]
Cardiovascular
Frequency not reported: Hypotension
Postmarketing reports: Tachycardia, dysrhythmias, orthostatic hypotension, bradycardia, palpitations[Ref]
Metabolic
Postmarketing reports: Hypoglycemia, hyperglycemia, acidosis, alkalosis, dehydration, hyperkalemia[Ref]
Other
Postmarketing reports: Malaise, asthenia, hypothermia, accidental overdose, non-accidental overdose, hearing loss, tinnitus[Ref]
Hepatic
Oxycodone-aspirin:
Postmarketing reports: Transient elevations of hepatic enzymes, hepatitis, Reye syndrome
Aspirin:
Frequency not reported: Reversible hepatotoxicity[Ref]
Psychiatric
Frequency not reported: Euphoria, dysphoria
Postmarketing reports: Agitation, confusion, anxiety, mental impairment, drug dependence, drug abuse, depression, nervousness, hallucination[Ref]
Dermatologic
Frequency not reported: Pruritus
Postmarketing reports: Urticaria, rash, flushing, increased sweating[Ref]
Musculoskeletal
Postmarketing reports: Rhabdomyolysis
Ocular
Postmarketing reports: Miosis, visual disturbances, red eye
Genitourinary
Frequency not reported: Urinary retention, interstitial nephritis, proteinuria
Respiratory
Frequency not reported: Apnea, respiratory arrest, respiratory depression
Postmarketing reports: Bronchospasm, dyspnea, hyperpnea, pulmonary edema, tachypnea, hypoventilation, laryngeal edema
Endocrine
Opioids:
Postmarketing reports: Adrenal insufficiency, androgen deficiency
Adrenal insufficiency and androgen deficiency have been reported with opioid use, most often with chronic use.
