Summary
Commonly reported side effects of plerixafor include: diarrhea, dizziness, injection site reaction, nausea, arthralgia, fatigue, headache, and vomiting. Other side effects include: flatulence. Continue reading for a comprehensive list of adverse effects.
Applies to plerixafor: subcutaneous solution.
Serious side effects of Plerixafor
Along with its needed effects, plerixafor may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking plerixafor:
More common
- Bleeding gums
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- collection of blood under the skin
- coughing up blood
- deep, dark purple bruise
- difficulty in breathing or swallowing
- dizziness
- feeling of heat
- flushing, redness of the skin
- hard lump
- headache
- hives or welts, itching, skin rash
- increased menstrual flow or vaginal bleeding
- irritation
- nosebleeds
- pain
- paralysis
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- swelling
- unusually warm skin
Rare
- Chills
- cold sweats
- confusion
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
- fainting
- fast heartbeat
- swelling around the eyes
- tightness in the chest
- weakness
Incidence not known
- Cough
- feeling of fullness
- pain in the left upper stomach or around the left shoulder
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- stomach pain
- unusual tiredness or weakness
Other side effects of Plerixafor
Some side effects of plerixafor may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bloated feeling
- diarrhea
- difficulty in moving
- excess air or gas in the stomach or bowels
- muscle pain or stiffness
- nausea
- pain in the joints
- passing gas
- trouble sleeping
- vomiting
Less common
- Belching
- bone pain
- difficulty having a bowel movement
- dry mouth
- general feeling of discomfort or illness
- heartburn
- increased sweating
- indigestion
- pressure in the stomach
- stomach discomfort or upset
- swelling of the abdominal or stomach area
Incidence not known
- Abnormal dreams and nightmares
For Healthcare Professionals
Applies to plerixafor: subcutaneous solution.
Gastrointestinal
Very common (10% or more): Diarrhea (up to 37%), nausea (up to 34%), vomiting (up to 10%)
Common (1% to 10%): Flatulence, abdominal pain, abdominal distension, dry mouth, stomach discomfort, hypoesthesia oral, constipation, dyspepsia[Ref]
Local
Very common (10% or more): Injection site reactions (up to 34%)[Ref]
Other
Very common (10% or more): Fatigue (up to 27%)
Common (1% to 10%): Malaise[Ref]
Nervous system
Very common (10% or more): Headache (up to 22%), paresthesia (up to 20.6%), dizziness (up to 11%)
Uncommon (0.1% to 1%): Vasovagal reactions[Ref]
Musculoskeletal
Very common (10% or more): Arthralgia (up to 13%)
Common (1% to 10%): Musculoskeletal pain[Ref]
Dermatologic
Common (1% to 10%): Hyperhidrosis, erythema[Ref]
Hematologic
Common (1% to 10%): Hyperleukocytosis
Frequency not reported: Thrombocytopenia
Postmarketing reports: Splenomegaly and splenic rupture[Ref]
Psychiatric
Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Abnormal dreams, nightmares[Ref]
Immunologic
Uncommon (0.1% to 1%): Allergic reactions
Postmarketing reports: Anaphylactic reactions including anaphylactic shock[Ref]
Cardiovascular
Rare (less than 0.1%): Myocardial infarction[Ref]
