By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Beta-lactamase inhibitors > Ampicillin and sulbactam > Ampicillin and sulbactam Pregnancy and Breastfeeding Warnings
Beta-lactamase inhibitors

Ampicillin / sulbactam Pregnancy and Breastfeeding Warnings

Contents
Ampicillin and sulbactam Pregnancy Warnings Ampicillin and sulbactam Breastfeeding Warnings

Ampicillin and sulbactam Pregnancy Warnings

This drug should be used during pregnancy only if clearly needed.

US FDA pregnancy category: B

Animal studies have failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy.

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

See references

Ampicillin and sulbactam Breastfeeding Warnings

Candidiasis and diarrhea have been reported in an infant exposed to ampicillin via breast milk; causality unknown.

Milk levels were 0.3 to 0.9 mg/L in 3 mothers who received ampicillin 2 g IM daily and 0.4 to 0.9 mg/L in 3 mothers who received 4 g IM daily. Peak milk levels were observed 3 hours postdose. It was estimated that the breastfed infant received 0.08 to 0.2 mg ampicillin daily with such doses.

Milk ampicillin levels averaged 0.11, 0.21, 0.17, 0.27, and 0.26 mg/L at 30 minutes, 1 hour, 2 hours, 4 hours, and 6 hours after the dose, respectively, in 15 women receiving ampicillin 500 mg IM 4 times a day.

Two hours after a single dose of ampicillin 2 g IV, milk levels averaged 1.1 mg/L.

Milk was collected at random times after doses of sulbactam 0.5 or 1 g infused IV over 20 minutes. Milk levels averaged 0.52 mg/L during the first 8 hours postdose and the highest level was 2.8 mg/L; milk levels varied slightly over that period and there was little difference between the 2 doses. Levels obtained 10.5 to 20.5 hours postdose were 0.12 to 1.2 mg/L.

In a study, postpartum women with endometritis received ampicillin 1 g plus sulbactam 0.5 g or ampicillin 2 g plus sulbactam 1 g infused IV over 20 minutes. Ampicillin milk levels averaged 1.7 mg/L and the highest level was 3 mg/L. Sulbactam milk levels averaged 0.58 mg/L and the highest level was 2.8 mg/L.

Five nursing mothers reported taking oral ampicillin (dose not provided) in a prospective follow-up study. One mother reported diarrhea in her infant. Neither rash nor candidiasis was observed in exposed infants.

During a small and controlled prospective study, mothers monitored their infants for signs of side effects (furring of the tongue, feeding difficulties, changes in stool frequency and consistency, diaper rash, skin rash), weight change, and jaundice. These parameters were not statistically different when infants of control mothers and of mothers taking oral ampicillin were compared.

Use is considered acceptable; caution is recommended.

Excreted into human milk: Yes (both components in small amounts)

Comments:
-Low levels in milk are not expected to cause harmful effects in the nursing infant.
-Ampicillin is considered compatible with breastfeeding by the WHO.
-Sulbactam is considered compatible with breastfeeding by the American Academy of Pediatrics.

See references

Share this Article
Latest News
Medical News

Obesity, unhealthy lifestyles may cause heart to age by 5–45 years

May 08, 2025
Aging: As little as 5 minutes of exercise may keep the brain healthy
Prostate cancer: Simple urine test may help with early detection
Cancer treatment side effects: Exercise may reduce pain, fatigue
Alzheimer's: Exercising in middle age may reduce beta-amyloid in brain...
Heart disease: Just 3 minutes of 'incidental activity' may lower...
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by