Carboprost Pregnancy Warnings
Carboprost does not appear to directly affect the placental unit; therefore, it is possible that a previable fetus aborted by carboprost could exhibit transient life signs. Studies in animals do not indicate teratogenicity; however, reproductive toxicity has been shown and any dose, which produces increased uterine tone, could put the embryo or fetus at risk.
US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
UK: Contraindicated
US: The manufacturer makes no recommendation regarding use during pregnancy.
US FDA pregnancy category: C
Comments:
-There are no clinical data on the effects of this drug on fertility.
-The benzyl alcohol excipient has been associated with a fatal "gasping syndrome" in premature infants.
See references
