Chlorpheniramine/dextromethorphan/phenylephrine has been assigned to pregnancy category C by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy. Chlorpheniramine/dextromethorphan/phenylephrine is only recommended for use during pregnancy when benefit outweighs risk.

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There are no data on the excretion of chlorpheniramine/dextromethorphan/phenylephrine into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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