Note: This document contains side effect information about rifapentine. Some dosage forms listed on this page may not apply to the brand name Priftin.
Summary
More frequent side effects include: diarrhea. Continue reading for a comprehensive list of adverse effects.
Applies to rifapentine: oral tablets.
Side effects include:
Neutropenia, increased AST/ALT, pyuria.
For Healthcare Professionals
Applies to rifapentine: oral tablet.
General
The most common side effects with the regimen for active pulmonary tuberculosis included anemia, lymphopenia, hemoptysis, neutropenia, cough, thrombocytosis, increased sweating, increased ALT, increased AST, back pain, rash, anorexia, arthralgia, increased blood urea, and headache. The most common side effect with the regimen for latent tuberculosis infection was hypersensitivity reaction.[Ref]
Cardiovascular
Frequency not reported: Tachycardia, palpitation, orthostatic hypotension, pericarditis, hematoma, thrombosis, flushing, hypotension[Ref]
Dermatologic
Common (1% to 10%): Increased sweating/hyperhidrosis, rash, pruritus/itching, maculopapular rash
Uncommon (0.1% to 1%): Skin reaction
Frequency not reported: Purpura, urticaria, skin discoloration, angioedema
Postmarketing reports: Severe cutaneous adverse reactions (e.g., Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms [DRESS] syndrome)[Ref]
Gastrointestinal
Common (1% to 10%): Nausea, dyspepsia, vomiting, diarrhea, abdominal pain
Frequency not reported: Clostridioides difficile-associated diarrhea, gastritis, esophagitis, pancreatitis, salivary gland enlargement, constipation, dry mouth, esophageal irritation[Ref]
Genitourinary
Frequency not reported: Hematuria, vaginitis, vaginal hemorrhage, leukorrhea, vulvovaginal candidiasis, vulvovaginal pruritus[Ref]
Hematologic
Very common (10% or more): Anemia (up to 11.4%), lymphopenia (up to 10.5%)
Common (1% to 10%): Neutropenia, thrombocytosis, leukocytosis, thrombocytopenia, lymphadenopathy
Frequency not reported: Leukopenia, lymphocytosis[Ref]
Hepatic
Common (1% to 10%): Increased ALT, increased AST, hepatotoxicity
Uncommon (0.1% to 1%): Hepatitis
Frequency not reported: Bilirubinemia, hepatomegaly, jaundice[Ref]
Hypersensitivity
Common (1% to 10%): Hypersensitivity/hypersensitivity reaction (including hypotension, urticaria, angioedema, acute bronchospasm, conjunctivitis; OR weakness, fatigue, nausea, vomiting, headache, fever, aches, sweats, dizziness, shortness of breath, flushing, chills)
Frequency not reported: Anaphylaxis[Ref]
Metabolic
Common (1% to 10%): Anorexia
Frequency not reported: Hyperglycemia, hyperuricemia, gout, hyperkalemia, decreased appetite, hyperlipidemia[Ref]
Musculoskeletal
Common (1% to 10%): Back pain, arthralgia
Frequency not reported: Arthritis, myalgia/muscle pain, myositis, rhabdomyolysis[Ref]
Nervous system
Common (1% to 10%): Headache, dizziness
Frequency not reported: Somnolence, convulsion, paresthesia, peripheral neuropathy, syncope[Ref]
Ocular
Common (1% to 10%): Conjunctivitis[Ref]
Other
Common (1% to 10%): Fever/pyrexia
Frequency not reported: Increased alkaline phosphatase, asthenia, facial edema, fungal infection, abortion, death, fatigue, chest pain, chills, feeling jittery, viral infection, aches, body fluid discoloration, weakness, influenza-like syndrome
Psychiatric
Frequency not reported: Anxiety, confusion, depression, disorientation, suicidal ideation[Ref]
Renal
Common (1% to 10%): Increased blood urea
Frequency not reported: Azotemia[Ref]
Respiratory
Common (1% to 10%): Hemoptysis, coughing/cough
Frequency not reported: Dysphonia, dyspnea/shortness of breath, pneumonitis, pulmonary fibrosis, asthma, bronchospasm, laryngeal edema, laryngitis, pharyngitis, oropharyngeal pain, bronchial hyperactivity, epistaxis, acute bronchospasm[Ref]
