Note: This document contains side effect information about lisinopril. Some dosage forms listed on this page may not apply to the brand name Prinivil.
Summary
Common side effects of Prinivil include: dizziness, hypotension, hyperkalemia, increased blood urea nitrogen, and increased serum creatinine. Other side effects include: headache. Continue reading for a comprehensive list of adverse effects.
Applies to lisinopril: oral extemporaneous suspension, oral tablets.
Warning
- May cause fetal and neonatal morbidity and mortality if used during pregnancy.1 2 3 4 74 75 (See Fetal/Neonatal Morbidity and Mortality under Cautions.)
- If pregnancy is detected, discontinue lisinopril as soon as possible.1 2 3 4 75
Side effects include:
Patients with hypertension: Headache, dizziness, cough, fatigue, diarrhea, upper respiratory tract infection, nausea. With fixed combination preparation, muscle cramps, asthenia, orthostatic effects, paresthesia.
Patients with heart failure: Dizziness, hypotension, headache, diarrhea, chest pain, nausea, abdominal pain, rash, upper respiratory tract infection.
Patients with acute MI: Hypotension, renal dysfunction.
For Healthcare Professionals
Applies to lisinopril: oral solution, oral tablet.
Cardiovascular
Very common (10% or more): Hypotension (11%)
Common (1% to 10%): Chest pain, angina pectoris, orthostatic hypotension, palpitations
Uncommon (0.1% to 1%): Angioneurotic edema, myocardial infarction or cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon[Ref]
Hypotension is most likely in patients who are sodium and intravascular volume depleted. In large studies, patients have reported "heart pounding" and chest pain, although the relationship to lisinopril is questionable.[Ref]
Renal
Common (1% to 10%): Creatinine increased (10%)
Very rare (less than 0.01%): Renal insufficiency[Ref]
Nervous system
Very common (10% or more): Dizziness (19%)
Common (1% to 10%): Headache, syncope
Uncommon (0.1% to 1%): Paresthesias[Ref]
Respiratory
Common (1% to 10%): Creatinine increased (10%)
Uncommon (0.1% to 1%): Rhinitis
Very rare (less than 0.01%): Bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonia[Ref]
A study has revealed a significantly higher incidence of discontinuation of angiotensin converting enzyme inhibitor therapy due to cough among black patients compared with nonblack patients (9.6% vs. 2.4%).[Ref]
Metabolic
Common (1% to 10%): Hyperkalemia
Frequency not reported: Gout, hypoglycemia in diabetic patients receiving ACE inhibitors when concurrently treated with oral antidiabetic agents or insulin[Ref]
Gastrointestinal
Common (1% to 10%): Diarrhea, nausea, vomiting
Frequency not reported: Pancreatitis, constipation, flatulence, dry mouth, taste disturbance[Ref]
Hypersensitivity
Uncommon (0.1% to 1%): Angioedema[Ref]
Dermatologic
Uncommon (0.1% to 1%): Rash, pruritus, erythema
Rare (0.01% to 0.1%): Alopecia, urticaria, psoriasis, hypersensitivity/angioedema, angioneurotic edema of the face, extremities, lips, tongue, glottis, and/or larynx
Very rare (less than 0.01%): Sweating, skin lesions, skin infections, pemphigus, toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, cutaneous pseudolymphoma
Frequency not reported: Photosensitivity, flushing, diaphoresis[Ref]
Hematologic
Very rare (less than 0.01%): Bone marrow depression, hemolytic anemia, leukopenia/neutropenia, thrombocytopenia, decreases in hemoglobin, decreases in hematocrit[Ref]
Psychiatric
Rare (0.01% to 0.1%): Memory impairment, confusion, somnolence, irritability, nervousness, hallucinations
Very rare (less than 0.01%): Mania
Hepatic
Common (1% to 10%): Creatinine increased
Very rare (less than 0.01%): Cholestatic jaundice that progresses to fulminant hepatic necrosis and sometimes death (discontinue of therapy if jaundice or markedly elevated hepatic serum enzymes develop)
Endocrine
Very rare (less than 0.01%): Diabetes, syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Other
Common (1% to 10%): Cough
Frequency not reported: Fatigue, asthenia, orthostatic effects, tinnitus, olfactory disturbance
Genitourinary
Uncommon (0.1% to 1%): Impotence
Rare (less than 0.1%): Gynecomastia
Frequency not reported: Proteinuria