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Home > Drugs > Rifapentine (monograph) > Rifapentine (monograph) Side Effects
Drugs

Rifapentine Side Effects

Summary

More frequently reported side effects include: diarrhea. Continue reading for a comprehensive list of adverse effects.

Applies to rifapentine: oral tablets.

Side effects include:

Neutropenia, increased AST/ALT, pyuria.

For Healthcare Professionals

Applies to rifapentine: oral tablet.

General

The most common side effects with the regimen for active pulmonary tuberculosis included anemia, lymphopenia, hemoptysis, neutropenia, cough, thrombocytosis, increased sweating, increased ALT, increased AST, back pain, rash, anorexia, arthralgia, increased blood urea, and headache. The most common side effect with the regimen for latent tuberculosis infection was hypersensitivity reaction.[Ref]

Cardiovascular

Frequency not reported: Tachycardia, palpitation, orthostatic hypotension, pericarditis, hematoma, thrombosis, flushing, hypotension[Ref]

Dermatologic

Common (1% to 10%): Increased sweating/hyperhidrosis, rash, pruritus/itching, maculopapular rash

Uncommon (0.1% to 1%): Skin reaction

Frequency not reported: Purpura, urticaria, skin discoloration, angioedema

Postmarketing reports: Severe cutaneous adverse reactions (e.g., Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms [DRESS] syndrome)[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, dyspepsia, vomiting, diarrhea, abdominal pain

Frequency not reported: Clostridioides difficile-associated diarrhea, gastritis, esophagitis, pancreatitis, salivary gland enlargement, constipation, dry mouth, esophageal irritation[Ref]

Genitourinary

Frequency not reported: Hematuria, vaginitis, vaginal hemorrhage, leukorrhea, vulvovaginal candidiasis, vulvovaginal pruritus[Ref]

Hematologic

Very common (10% or more): Anemia (up to 11.4%), lymphopenia (up to 10.5%)

Common (1% to 10%): Neutropenia, thrombocytosis, leukocytosis, thrombocytopenia, lymphadenopathy

Frequency not reported: Leukopenia, lymphocytosis[Ref]

Hepatic

Common (1% to 10%): Increased ALT, increased AST, hepatotoxicity

Uncommon (0.1% to 1%): Hepatitis

Frequency not reported: Bilirubinemia, hepatomegaly, jaundice[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity/hypersensitivity reaction (including hypotension, urticaria, angioedema, acute bronchospasm, conjunctivitis; OR weakness, fatigue, nausea, vomiting, headache, fever, aches, sweats, dizziness, shortness of breath, flushing, chills)

Frequency not reported: Anaphylaxis[Ref]

Metabolic

Common (1% to 10%): Anorexia

Frequency not reported: Hyperglycemia, hyperuricemia, gout, hyperkalemia, decreased appetite, hyperlipidemia[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, arthralgia

Frequency not reported: Arthritis, myalgia/muscle pain, myositis, rhabdomyolysis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Frequency not reported: Somnolence, convulsion, paresthesia, peripheral neuropathy, syncope[Ref]

Ocular

Common (1% to 10%): Conjunctivitis[Ref]

Other

Common (1% to 10%): Fever/pyrexia

Frequency not reported: Increased alkaline phosphatase, asthenia, facial edema, fungal infection, abortion, death, fatigue, chest pain, chills, feeling jittery, viral infection, aches, body fluid discoloration, weakness, influenza-like syndrome

Psychiatric

Frequency not reported: Anxiety, confusion, depression, disorientation, suicidal ideation[Ref]

Renal

Common (1% to 10%): Increased blood urea

Frequency not reported: Azotemia[Ref]

Respiratory

Common (1% to 10%): Hemoptysis, coughing/cough

Frequency not reported: Dysphonia, dyspnea/shortness of breath, pneumonitis, pulmonary fibrosis, asthma, bronchospasm, laryngeal edema, laryngitis, pharyngitis, oropharyngeal pain, bronchial hyperactivity, epistaxis, acute bronchospasm[Ref]

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