Note: This document contains side effect information about rucaparib. Some dosage forms listed on this page may not apply to the brand name Rubraca.
Applies to rucaparib: oral tablet.
Serious side effects of Rubraca
Along with its needed effects, rucaparib (the active ingredient contained in Rubraca) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking rucaparib:
More common
- Black, tarry stools
- bleeding gums
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blood in the urine
- body aches or pain
- chills
- cough
- difficulty in breathing
- ear congestion
- fever
- headache
- loss of voice
- lower back or side pain
- muscle aches
- nasal congestion
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- rapid weight gain
- sneezing
- sore throat
- stuffy or runny nose
- tingling of the hands or feet
- trouble breathing
- trouble breathing
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
Less common
- Redness, swelling, or pain of the skin
- scaling of the skin on the hands and feet
- tenderness of the palms and soles
- tingling of the hands and feet
- ulceration of the skin
Other side effects of Rubraca
Some side effects of rucaparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Belching
- change in taste
- constipation
- decreased appetite
- diarrhea
- discouragement
- dizziness
- feeling sad or empty
- heartburn
- increased sensitivity of the skin to sunlight
- indigestion
- irritability
- itching, skin rash
- lack of appetite
- lack or loss of strength
- loss of interest or pleasure
- loss of taste
- nausea
- redness or other discoloration of the skin
- severe sunburn
- stomach discomfort, upset, or pain
- stomach distention
- swelling or inflammation of the mouth
- trouble concentrating
- trouble sleeping
- vomiting
For Healthcare Professionals
Applies to rucaparib: oral tablet.
General
-The most common adverse reactions reported in at least 20% of patients were nausea, asthenia/fatigue, vomiting, anemia, constipation, dysgeusia, decreased appetite, diarrhea, abdominal pain, dyspnea, and thrombocytopenia.
-The most common laboratory abnormalities reported in at least 35% of patients were increased creatinine, increased ALT, increased AST, decreased hemoglobin, decreased lymphocytes, increased cholesterol, decreased platelets, and decreased absolute neutrophil count.
-Adverse reactions led to dose reduction or interruption in 62% of patients (most frequently from anemia [27%] and asthenia/fatigue [22%]), and to dose discontinuation in 10% of patients (most frequently from asthenia/fatigue [2%]).[Ref]
Renal
Very common (10% or more): Increased creatinine (92%)[Ref]
Gastrointestinal
Very common (10% or more): Nausea (77%), vomiting (46%), constipation (40%), diarrhea (34%), abdominal pain (32%)[Ref]
Other
Very common (10% or more): Asthenia/fatigue (77%), pyrexia (11%)[Ref]
Hepatic
Very common (10% or more): Increased ALT (74%), increased AST (73%)[Ref]
Hematologic
Very common (10% or more): Decreased hemoglobin (67%), decreased lymphocytes (45%), anemia (44%), decreased platelets (39%), decreased absolute neutrophil count (35%), thrombocytopenia (21%), neutropenia (15%)
Common (1% to 10%): Febrile neutropenia[Ref]
Metabolic
Very common (10% or more): Decreased appetite (39%), increased cholesterol (40%)[Ref]
Nervous system
Very common (10% or more): Dysgeusia (39%), dizziness (17%)[Ref]
Respiratory
Very common (10% or more): Dyspnea (21%)[Ref]
Dermatologic
Very common (10% or more): Dermatitis/Rash (13%), photosensitivity reaction (10%)
Common (1% to 10%): Pruritus, palmar-plantar erythrodysesthesia syndrome[Ref]
Oncologic
Uncommon (0.1% to 1%): Myelodysplastic syndrome, acute myeloid leukemia[Ref]
