Note: This document contains side effect information about tedizolid. Some dosage forms listed on this page may not apply to the brand name Sivextro.
Summary
More frequent side effects include: diarrhea. Continue reading for a comprehensive list of adverse effects.
Applies to tedizolid: oral tablet. Other dosage forms:
- intravenous powder for solution
Serious side effects of Sivextro
Along with its needed effects, tedizolid (the active ingredient contained in Sivextro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tedizolid:
Less common
- Blurred vision
- chest tightness
- diarrhea
- dizziness
- fast, slow, pounding, or irregular heartbeat or pulse
- fever
- headache
- hives or welts, itching, or skin rash
- hoarseness
- irritation
- itching of the vagina or genitals
- joint pain, stiffness, or swelling
- nervousness
- pale skin
- pounding in the ears
- redness of the skin
- severe stomach cramps and pain
- sore mouth or tongue
- stomach tenderness
- swelling of the eyelids, face, lips, hands, or feet
- thick, white vaginal discharge with mild or no odor
- trouble breathing or swallowing
- unusual bleeding or bruising
- unusual tiredness or weakness
- watery or severe diarrhea, which may also be bloody
- white patches in the mouth or on the tongue
Incidence not known
- Black, tarry stools
- blood in the urine or stools
- chills
- cough
- lower back or side pain
- painful or difficult urination
- pinpoint red spots on the skin
Other side effects of Sivextro
Some side effects of tedizolid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Nausea
Less common
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- double vision
- feeling of warmth
- feeling that you cannot keep your eyes open
- increased sensitivity of the eyes to light
- redness of the face, neck, arms, and occasionally, upper chest
- seeing floating spots before the eyes
- sore neck, shoulders, or back
- sore, tired, burning, or itching eyes
- trouble concentrating
- trouble sleeping
- vomiting
- watery or dry eyes
For Healthcare Professionals
Applies to tedizolid: intravenous powder for injection, oral tablet.
General
The most common side effects were nausea, headache, diarrhea, vomiting, and dizziness. Median time to onset was 5 days.[Ref]
Gastrointestinal
Common (1% to 10%): Nausea, diarrhea, vomiting
Uncommon (0.1% to 1%): Clostridioides difficile colitis, oral candidiasis, abdominal pain, constipation, abdominal discomfort, dry mouth, dyspepsia, upper abdominal pain, flatulence, gastroesophageal reflux disease, hematochezia, retching[Ref]
Nervous system
Common (1% to 10%): Headache, dizziness, peripheral neuropathy
Uncommon (0.1% to 1%): Somnolence, dysgeusia, tremor, hypoesthesia, paresthesia
Frequency not reported: VIIth nerve paralysis[Ref]
Hematologic
Common (1% to 10%): Decreased hemoglobin, decreased platelet count
Uncommon (0.1% to 1%): Decreased absolute neutrophil count, lymphadenopathy, decreased WBC count
Frequency not reported: Anemia[Ref]
Decreased hemoglobin (less than 10.1 g/dL in males; less than 9 g/dL in females), platelet count (less than 112 x 10[3]/mm3), and absolute neutrophil count (less than 0.8 x 10[3]/mm3) were reported in 3.4%, 2.1%, and 0.4% of patients, respectively.[Ref]
Dermatologic
Common (1% to 10%): Generalized pruritus
Uncommon (0.1% to 1%): Dermatophytosis, pruritus, urticaria, hyperhidrosis, rash, alopecia, erythematous rash, generalized rash, acne, allergic pruritus, maculopapular rash, popular rash, pruritic rash
Frequency not reported: Dermatitis[Ref]
Other
Common (1% to 10%): Fatigue
Uncommon (0.1% to 1%): Fungal infection, abscess, flushing, hot flush, chills, pyrexia, peripheral edema, grip strength decreased
Local
Common (1% to 10%): Infusion/injection-related side effects (including but not limited to phlebitis, injection/infusion-site pain, injection/infusion-site swelling, injection-site reaction, injection-site erythema, injection-site induration, infusion-related reaction), infusion site reactions (phlebitis)
Uncommon (0.1% to 1%): Infusion-related reactions, infusion site pain[Ref]
Cardiovascular
Uncommon (0.1% to 1%): Bradycardia
Frequency not reported: Palpitations, tachycardia, hypertension[Ref]
Hepatic
Uncommon (0.1% to 1%): Elevated hepatic transaminases
Frequency not reported: Increased ALT, increased AST, increased GGT, abnormal liver function tests[Ref]
Psychiatric
Uncommon (0.1% to 1%): Insomnia, sleep disorder, anxiety, nightmare, irritability[Ref]
Hypersensitivity
Uncommon (0.1% to 1%): Drug hypersensitivity
Musculoskeletal
Uncommon (0.1% to 1%): Arthralgia, muscle spasms, back pain, limb discomfort, neck pain
Metabolic
Uncommon (0.1% to 1%): Dehydration, inadequately controlled diabetes mellitus, hyperkalemia
Ocular
Uncommon (0.1% to 1%): Optic nerve disorders, blurred vision, vitreous floaters
Frequency not reported: Asthenopia, visual impairment[Ref]
Respiratory
Uncommon (0.1% to 1%): Respiratory tract infection, cough, nasal dryness, pulmonary congestion
Genitourinary
Uncommon (0.1% to 1%): Vulvovaginal mycotic infection, vulvovaginal candidiasis, abnormal urine odor, vulvovaginal pruritus