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Home > Drugs > Sulfacetamide (monograph) > Sulfacetamide (monograph) Side Effects
Drugs

Sulfacetamide sodium ophthalmic Side Effects

Applies to sulfacetamide sodium ophthalmic: ophthalmic ointment, ophthalmic solution, ophthalmic suspension.

Side effects include:

Local irritation, transient stinging or burning.

For Healthcare Professionals

Applies to sulfacetamide sodium ophthalmic: ophthalmic ointment, ophthalmic solution.

General

The side effects reported most often were local/conjunctival irritation, stinging, and burning.[Ref]

Ocular

Frequency not reported: Local/conjunctival irritation, stinging, burning, nonspecific conjunctivitis, conjunctival hyperemia, bacterial corneal ulcers, fungal corneal ulcers[Ref]

Hypersensitivity

Rare (less than 0.1%): Sensitivity reactions

Frequency not reported: Allergic reactions/hypersensitivity, local hypersensitivity progressing to fatal syndrome resembling systemic lupus erythematosus (SLE)[Ref]

At least 1 case of local hypersensitivity has been reported that progressed to a SLE-like fatal syndrome.[Ref]

Other

Frequency not reported: Secondary infections[Ref]

Dermatologic

Sulfonamides:

-Frequency not reported: Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]

Fatalities reported rarely due to severe reactions to sulfonamides (including toxic epidermal necrolysis, Stevens-Johnson syndrome, fulminant hepatic necrosis, aplastic anemia, agranulocytosis, other blood dyscrasias).

Stevens-Johnson syndrome was reported in a patient with history of blistering drug reaction to an oral sulfonamide.[Ref]

Hematologic

Sulfonamides:

-Frequency not reported: Agranulocytosis, aplastic anemia, other blood dyscrasias[Ref]

Fatalities reported rarely due to severe reactions to sulfonamides (including toxic epidermal necrolysis, Stevens-Johnson syndrome, fulminant hepatic necrosis, aplastic anemia, agranulocytosis, other blood dyscrasias).[Ref]

Hepatic

Fatalities reported rarely due to severe reactions to sulfonamides (including toxic epidermal necrolysis, Stevens-Johnson syndrome, fulminant hepatic necrosis, aplastic anemia, agranulocytosis, other blood dyscrasias).[Ref]

Sulfonamides:

-Frequency not reported: Fulminant hepatic necrosis[Ref]

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