Note: This document contains side effect information about solriamfetol. Some dosage forms listed on this page may not apply to the brand name Sunosi.
Applies to solriamfetol: oral tablet.
Serious side effects of Sunosi
Along with its needed effects, solriamfetol (the active ingredient contained in Sunosi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking solriamfetol:
More common
- Anxiety
Less common
- Agitation
- chest pain or discomfort
- cough
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling jittery
- irritability
- restlessness
- tightness of the chest
- tremor
- trouble breathing
- trouble sleeping
Other side effects of Sunosi
Some side effects of solriamfetol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Decreased appetite
- headache
- nausea
Less common
- Clenching, gnashing, or grinding teeth
- constipation
- decreased weight
- diarrhea
- dizziness
- dry mouth
- increased sweating
- stomach pain
- vomiting
For Healthcare Professionals
Applies to solriamfetol: oral tablet.
General
The more commonly reported adverse reactions have included headache, nausea, decreased appetite, insomnia, and anxiety.[Ref]
Cardiovascular
Increased systolic and diastolic blood pressure and heart rate occurred in a dose-dependent manner during clinical trials.
Common (1% to 10%): Palpitations, chest discomfort/pain
Frequency not reported: Increased blood pressure and heart rate
Psychiatric
Common (1% to 10%): Insomnia, anxiety (includes nervousness and panic attacks), irritability, jittery
Frequency not reported: Agitation, restlessness
Anxiety was more commonly reported at higher doses. Agitation and restlessness were reported in less than 2% of patients.
Gastrointestinal
Nausea, including vomiting, dry mouth, and vomiting were more common at higher doses. Bruxism and thirst were reported in less than 2% of patients.
Common (1% to 10%): Nausea (includes nausea and vomiting), dry mouth, constipation, diarrhea, abdominal pain
Frequency not reported: Bruxism, thirst
Metabolic
Decreased appetite was more common at higher doses. Decreased weight was reported in less than 2% of patients.
Common (1% to 10%): Decreased appetite
Frequency not reported: Decreased weight
Respiratory
Frequency not reported: Cough, dyspnea
Cough and dyspnea were reported in less than 2% of patients.
Nervous system
Headache was more common with higher doses. Disturbances in attention and tremor were reported in less than 2% of patients.
Very common (10% or more): Headache (16%)
Common (1% to 10%): Dizziness
Frequency not reported: Disturbances in attention, tremor
Dermatologic
Common (1% to 10%): Hyperhidrosis
