Note: This document contains side effect information about naloxone / oxycodone. Some dosage forms listed on this page may not apply to the brand name Targiniq ER.

Applies to naloxone / oxycodone: oral tablet extended release.

Cardiovascular

Common (1% to 10%): Hypertension, hypotension

Uncommon (0.1% to 1%): Angina pectoris, (especially in patients with history of coronary artery disease), palpitations, peripheral edema, chest pain

Rare (less than 0.1%): Syncope

Frequency not reported: Flushing, bradycardia, ST depression, supraventricular tachycardia^[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash, cold sweat

Postmarketing reports: Hyperhidrosis, exfoliative dermatitis, dry skin, urticaria^[Ref]

Endocrine

Common (1% to 10%): Hot flush^[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, abdominal pain, dry mouth, flatulence, vomiting, nausea, anorexia, increased appetite, gastroenteritis, dyspepsia, constipation

Frequency not reported: Thirst, eructation, colic, dysphagia, stomatitis, taste perversion, dental caries, ileus, flatulence^[Ref]

Genitourinary

Frequency not reported: Urinary tract infection, micturition urgency, ureteric spasm, erectile dysfunction, urinary retention, amenorrhea^[Ref]

Hepatic

Frequency not reported: Biliary colic, increased liver enzymes, biliary spasm, cholestasis^[Ref]

Hypersensitivity

Rare (less than 0.1%): Allergic reactions, anaphylactic reactions^[Ref]

Immunologic

Common (1% to 10%): Influenza

Rare (less than 0.1%): Herpes simplex

Frequency not reported: Lymphadenopathy^[Ref]

Metabolic

Common (1% to 10%): Loss of appetite

Rare (less than 0.1%): Dehydration, increased appetite

Frequency not reported: Increased serum triglycerides, hyponatremia^[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, fall, arthralgia, myalgia

Frequency not reported: Myalgia, neck pain, striated and nonstriated muscle spasms, muscle twitching, muscle rigidity, osteoarthritis, abnormal gait, hypertonia, involuntary muscle contractions, abnormal coordination^[Ref]

Nervous system

Common (1% to 10%): Headache, fatigue, dizziness, drug withdrawal syndrome, sedation, tremor, sinus headache, somnolence

Uncommon (0.1% to 1%): Disturbance in attention, paraesthesia, speech disorder, malaise

Rare (less than 0.1%): Convulsions (particularly in persons with epileptic disorder or predisposition to convulsions)

Frequency not reported: Syncope

Postmarketing reports: Raised intracranial pressure, sciatica, tremor, vertigo, drowsiness, paraesthesia, somnolence, speech disorder, amnesia, hypertonia, migraine, feeling hot and cold, chills, tinnitus^[Ref]

Ocular

Common (1% to 10%): Lacrimation increased

Uncommon (0.1% to 1%): Visual disturbances, miosis^[Ref]

Oncologic

Common (1% to 10%): Malignant neoplasm progression

Psychiatric

Common (1% to 10%): Drug abuse, anxiety, restlessness

Uncommon (0.1% to 1%): Abnormal thinking, confusion, depression, hallucination, altered mood, personality change, euphoric mood, decreased activity, psychomotor hyperactivity, agitation, nervousness, insomnia, perception disturbances (e.g., hallucination, derealization), reduced libido, mood changes, disorientation, dysphoria, nightmares^[Ref]

Respiratory

Common (1% to 10%): Dyspnea, rhinorrhea, yawning

Uncommon (0.1% to 1%): Respiratory depression, bronchial spasm, spasms of nonstriated muscles, suppression of the cough reflex

Frequency not reported: Bronchitis, nasopharyngitis, pharyngitis, voice alteration, sinusitis, lower respiratory tract infection, hiccup^[Ref]