Note: This document contains side effect information about tobramycin ophthalmic. Some dosage forms listed on this page may not apply to the brand name Tobrex.
Applies to tobramycin ophthalmic: ophthalmic ointment, ophthalmic solution.
Serious side effects of Tobrex
Along with its needed effects, tobramycin ophthalmic (the active ingredient contained in Tobrex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tobramycin ophthalmic:
Less common
- Itching, redness, swelling, or other sign of eye or eyelid irritation not present before use of this medicine
Symptoms of overdose
- Increased watering of the eyes
- itching, redness, or swelling of the eyes or eyelids
- painful irritation of the clear front part of the eye
Other side effects of Tobrex
Some side effects of tobramycin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Burning or stinging of the eyes
Eye ointments usually cause your vision to blur for a few minutes after application.
For Healthcare Professionals
Applies to tobramycin ophthalmic: ophthalmic ointment, ophthalmic solution.
General
The most frequently reported side effects included localized ocular toxicity and hypersensitivity reactions.[Ref]
Ocular
Common (1% to 10%): Conjunctival erythema, eye itching, lacrimation, lid itching, lid swelling, ocular discomfort, ocular hyperemia, punctate keratitis
Uncommon (0.1% to 1%): Blurred vision, conjunctival disorder, dry eye, eye discharge, eye pain, eye pruritus, eyelid disorder, eyelid edema, eyelid erythema, keratitis, lacrimation increased, visual impairment
Frequency not reported: Burning of the eyes, eye allergy, eye irritation, eyelid pruritus, stinging of the eyes[Ref]
Hypersensitivity
Common (1% to 10%): Hypersensitivity reactions
Frequency not reported: Anaphylactic reaction[Ref]
Dermatologic
Uncommon (0.1% to 1%): Dermatitis, dry skin, leukoderma, madarosis, pruritus, urticaria
Frequency not reported: Erythema multiforme, rash, Stevens-Johnson syndrome[Ref]
Other
Frequency not reported: Increased systemic toxicity[Ref]
The risk of systemic toxicity is higher in patients receiving systemic aminoglycosides concurrently; total serum concentration monitoring should be considered in this population.[Ref]
Local
Localized ocular toxicity included conjunctival erythema, eye itching, lacrimation, lid itching, lid swelling, ocular hyperemia, and punctate keratitis.[Ref]
Common (1% to 10%): Localized ocular toxicity
Uncommon (0.1% to 1%): Corneal abrasion, foreign body sensation in eyes[Ref]
Nervous system
Uncommon (0.1% to 1%): Headache[Ref]