Other names: CAR T Cell-Induced Cytokine Release Syndrome; Cytokine-Associated Toxicity

Cytokine release syndrome (CRS) is a group of symptoms that occur as a side effect to cancer immunotherapy treatment. Symptoms of CRS can be mild to moderate such as fever, chills, nausea, headache, rash, irritated throat, nausea and vomiting. Severe symptoms of CRS can include low blood pressure, heart problems and reduce oxygen levels, which can become life threatening. CRS happens when there is a large release of messenger proteins (cytokines) from immune cells that have been activated by immunotherapy treatment.

Drugs used to treat Cytokine Release Syndrome