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Home > Drugs > Treatments > Irritable Bowel Syndrome with Constipation

Medications for Irritable Bowel Syndrome with Constipation

Other names: Constipation-Predominant IBS; Constipation-Predominant Irritable Bowel Syndrome; IBS-C

Irritable bowel syndrome with constipation (IBS-C), the constipation-predominant subtype of IBS, affects around 34% of people with IBS. It is defined as constipation associated with abdominal pain that is generally relieved by passing a bowel motion (defecation). People with IBS-C are more likely to be older age and of lower socioeconomic status. More than 25% of their bowel movements are hard or lumpy, and loose or watery stools make up less than 25% of their bowel movements.

Research suggests people with IBS-C have a lower quality of life and more impairment in their day-to-day activities than people with other subtypes of IBS. 

Drugs used to treat Irritable Bowel Syndrome with Constipation

Name Drug Class Updated
Plecanatide Guanylate cyclase-C agonists 15-Aug-2023
Linaclotide Guanylate cyclase-C agonists 14-Aug-2023
Tenapanor NHE3 inhibitors 12-Aug-2023
Lubiprostone Chloride channel activators 11-Aug-2023
Amitiza Chloride channel activators 05-Aug-2023
Zelnorm Serotoninergic neuroenteric modulators 14-Jul-2023
Trulance Guanylate cyclase-C agonists 14-Jul-2023
Ibsrela NHE3 inhibitors 13-Jul-2023
Linzess Guanylate cyclase-C agonists 11-Jul-2023
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