Other names: Diabetic Hyperglycemic Hyperosmolar Coma; HONK, hyperosmolar non-ketotic coma; NKHHC; Nonketotic Hyperglycemic Hyperosmolar Coma

Nonketotic Hyperosmolar Syndrome is a complication seen in diabetes mellitus in which very marked hyperglycemia occurs (such as levels exceeding 800 mg/dL), causing osmotic shifts in water in brain cells, and resulting in coma. It can be fatal or lead to permanent neurologic damage. Ketoacidosis does not occur in these cases.

Drugs used to treat Nonketotic Hyperosmolar Syndrome