Note: This document contains side effect information about abaloparatide. Some dosage forms listed on this page may not apply to the brand name Tymlos.
Summary
Common side effects of Tymlos include: dizziness and hypercalciuria. Other side effects include: nausea and palpitations. Continue reading for a comprehensive list of adverse effects.
Applies to abaloparatide: subcutaneous solution.
Serious side effects of Tymlos
Along with its needed effects, abaloparatide (the active ingredient contained in Tymlos) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking abaloparatide:
More common
- Blood in the urine
- constipation
- depression
- loss of appetite
- loss of weight
- muscle weakness
- nausea or vomiting
- pain in the bone, joint, back, arms, or legs
- pain in the side, back, or stomach
- thirst
- unusual tiredness or weakness
Less common
- Fast, irregular, pounding, or racing heartbeat or pulse
Incidence not known
- Chest tightness
- cough
- difficulty swallowing
- dizziness
- fast heartbeat
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- trouble breathing
Other side effects of Tymlos
Some side effects of abaloparatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- difficulty in moving
- headache
- muscle pain or stiffness
Less common
- Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
- feeling of constant movement of self or surroundings
- sensation of spinning
- unusual bruising
Incidence not known
- Diarrhea
- full or bloated feeling
- general feeling of discomfort or illness
- itching, rash
- lack or loss of strength
- muscle spasms of the leg and back
- pressure in the stomach
- swelling of the stomach area
- trouble sleeping
- unusual drowsiness, dullness, or feeling of sluggishness
For Healthcare Professionals
Applies to abaloparatide: subcutaneous solution.
General
The most common side effects resulting in discontinuation were nausea, dizziness, headache, and palpitations.
Cardiovascular
Common (1% to 10%): Palpitations, tachycardia (including sinus tachycardia), orthostatic hypotension[Ref]
Dermatologic
Postmarketing reports: Pruritus, rash
Gastrointestinal
Common (1% to 10%): Nausea, upper abdominal pain, abdominal distention, diarrhea
Postmarketing reports: Abdominal distention, abdominal pain, constipation, diarrhea, vomiting[Ref]
Hypersensitivity
Postmarketing reports: Hypersensitivity and anaphylactic reaction
Immunologic
Very common (10% or more): Immunogenicity[Ref]
Local
Very common (10% or more): Redness at injection site (58%), edema at injection site (11%), pain at injection site (10%)
Common (1% to 10%): Contusion at injection site
Postmarketing reports: Injection site bruising, hemorrhage[Ref]
Metabolic
Very common (10% or more): Increased serum uric acid (25%)
Common (1% to 10%): Hypercalcemia[Ref]
Nervous system
Very common (10% or more): Dizziness (10%)
Common (1% to 10%): Headache
Postmarketing reports: Lethargy[Ref]
Other
Common (1% to 10%): Fatigue, vertigo
Postmarketing reports: Asthenia, malaise
Psychiatric
Postmarketing reports: Insomnia
Renal
Very common (10% or more): Hypercalciuria (20%)
Common (1% to 10%): Urolithiasis[Ref]
Respiratory
Postmarketing reports: Dyspnea
Musculoskeletal
Common (1% to 10%): Arthralgia, bone pain
Postmarketing reports: Bone pain, joint pain, back pain, extremity pain, leg and back muscle spasms
