Applies to typhoid vaccine, inactivated: intramuscular solution.

Serious side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Dizziness or passing out.

Other side effects

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Upset stomach.
• Headache.
• Irritation where the shot is given.
• Feeling tired or weak.
• Muscle pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to typhoid vaccine, inactivated: injectable suspension, intramuscular solution, oral delayed release capsule.

General

The most common adverse events were injection site reactions.^[Ref]

Local

Very common (10% or more): Tenderness (98%), pain (56%), induration (18%), soreness (13%), erythema (11%)

Common (1% to 10%): Swelling

Very rare (less than 0.01%): Edema^[Ref]

Local reactions usually resolved within 48 hours of vaccination.^[Ref]

Other

Very common (10% or more): Malaise (37%), fatigue (38%), feverish (subjective) (11.1%)

Common (1% to 10%): Fever of 100F or greater, decreased activity, elevated oral temperature, general aches

Postmarketing reports: Asthenia, flu-like episode^[Ref]

Nervous system

Very common (10% or more): Headache (27%)

Postmarketing reports: Syncope without convulsions, loss of consciousness, tremor, vasovagal syncope in response to injection^[Ref]

Hypersensitivity

Postmarketing reports: Anaphylaxis/anaphylactoid reactions including shock, serum sickness, allergic-type reactions such as pruritus, rash, urticaria, angioedema, difficulty breathing, or hypotension^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, vomiting

Postmarketing reports: Abdominal pain^[Ref]

Dermatologic

Common (1% to 10%): Itching

Very rare (less than 0.01%): Urticaria, rash^[Ref]

Musculoskeletal

Common (1% to 10%): Myalgia

Postmarketing reports: Arthralgia, cervical pain, polyarthritis^[Ref]

Hematologic

Postmarketing reports: Lymphadenopathy, neutropenia^[Ref]

Ocular

Postmarketing reports: Bilateral retinitis^[Ref]

Renal

Postmarketing reports: Glomerulonephritis^[Ref]

Respiratory

Postmarketing reports: Asthma^[Ref]