Summary
Commonly reported side effects of vincristine liposome include: anemia, constipation, neutropenia, and thrombocytopenia. Other side effects include: asthenia, increased serum aspartate aminotransferase, and intestinal obstruction. Continue reading for a comprehensive list of adverse effects.
Applies to vincristine liposome: intravenous suspension.
Warning
Intravenous route (Suspension)
VinCRIStine sulfate liposome is for IV use only and is fatal if given by other routes. Death has occurred with intrathecal use. VinCRIStine sulfate liposome injection has different dosage recommendations than vinCRIStine sulfate injection. Verify drug name and dose before preparation and administration to avoid overdosage.
Serious side effects
Along with its needed effects, vincristine liposome may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking vincristine liposome:
More common
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- blurred vision
- burning, tingling, numbness or pain in the hands, arms, feet, or legs
- chest pain or tightness
- chills
- confusion
- cough
- diarrhea
- dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
- fever
- lack or loss of strength
- lower back or side pain
- nausea
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- rapid breathing
- severe constipation
- severe vomiting
- sneezing
- sore throat
- stomach pain
- sweating
- trouble breathing
- ulcers, sores, or white spots in the mouth
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
Less common
- Blue lips, fingernails, or skin
- bone pain
- change in muscle reflexes
- coughing up blood
- dark urine
- headache
- irregular, fast or slow, or shallow breathing
- joint pain, stiffness, or swelling
- light-colored stools
- muscle pain or weakness
- stomach pain, continuing
- swelling of the feet or lower legs
- vomiting
- weakness of the muscles in your face
- yellow eyes or skin
Other side effects
Some side effects of vincristine liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Anxiety
- mental depression
- nightmares or unusually vivid dreams
Incidence not known
- Redness, pain, or swelling at the injection site
For Healthcare Professionals
Applies to vincristine liposome: intravenous kit.
Cardiovascular
Common (1% to 10%): Hypotension, cardiac arrest, vascular disorder[Ref]
Gastrointestinal
Very common (10% or more): Nausea (52%), diarrhea (37%), decreased appetite (33%)
Common (1% to 10%): Constipation, abdominal pain, ileus/colonic pseudo-obstruction[Ref]
General
Side effects that have resulted in non-leukemia related deaths: Brain infarct, intracerebral hemorrhage, liver failure, multisystem organ failure, pneumonia and septic shock, respiratory failure, pulmonary hemorrhage, sudden cardiac death[Ref]
Hematologic
Very common (10% or more): Febrile neutropenia (38%), neutropenia (31.3%), anemia (34%), thrombocytopenia (16.9%)
Frequency not reported: Neutropenia, thrombocytopenia[Ref]
Metabolic
Frequency not reported: Increased aspartate aminotransferase, tumor lysis syndrome[Ref]
Musculoskeletal
Frequency not reported: Asthenia, muscular weakness, musculoskeletal pain[Ref]
Nervous system
Very common (10% or more): Peripheral neuropathy (39%), insomnia (32%)
Common (1% to 10%): Peripheral sensory and motor neuropathy, decreased vibratory sense, facial palsy, hyporeflexia, asthenia[Ref]
Other
Very common (10% or more): Pyrexia (15%), fatigue (12%)[Ref]
Psychiatric
Frequency not reported: Mental status changes[Ref]
Respiratory
Common (1% to 10%): Respiratory distress, respiratory failure, pneumonia[Ref]
Immunologic
Common (1% to 10%): Septic shock, staphylococcal bacteremia[Ref]
Local
Frequency not reported: Extravasation tissue injury[Ref]
Hepatic
Frequency not reported: Hepatic toxicity[Ref]
Oncologic
Very common (10% or more): Pyrexia (43%), fatigue (41%)
Frequency not reported: Pain, septic shock, staphylococcal bacteremia[Ref]
