Note: This document contains side effect information about tegaserod. Some dosage forms listed on this page may not apply to the brand name Zelnorm.

Applies to tegaserod: oral tablet.

Cardiovascular

Cardiovascular side effects have included hypotension, angina pectoris, syncope, arrhythmia, bundle branch block, supraventricular tachycardia, and flushing. A case of myocardial infarction has been reported.^[Ref]

Myocardial infarction has been reported in a 64-year-old male after receiving two doses of tegaserod 6 mg.^[Ref]

Nervous system

Nervous system side effects have included headache, dizziness, migraine, insomnia, vertigo, and Raynaud's phenomenon.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included abdominal pain, diarrhea, nausea, flatulence, abdominal distention and pain, vomiting, dyspepsia, gastritis, gastroesophageal reflux, hemorrhoids, and proctalgia. Irritable colon, fecal incontinence, tenesmus, increased appetite, eructation, appendicitis, bilirubinemia, subileus, sphincter of Oddi spasm, bile duct stone, ischemic colitis, mesenteric ischemia, gangrenous bowel, rectal bleeding, and increases in abdominal surgeries, primarily cholecystectomies, have also been reported; however, causality was not clearly established.^[Ref]

Hepatic

Hepatic side effects have included increased SGOT and SGPT. Hepatitis, elevation in ALT, AST, and bilirubin have been reported during postmarketing experience.^[Ref]

Metabolic

Metabolic side effects have included increase in appetite, hypokalemia and hypovolemia secondary to diarrhea, and increased creatine phosphokinase.^[Ref]

Musculoskeletal

Musculoskeletal side effects have included back pain, arthropathy, and myalgia. Other effects, regardless of causality, have included cramps.^[Ref]

Oncologic

Oncologic side effects have included breast carcinoma.^[Ref]

Psychiatric

Psychiatric side effects have included attempted suicide, impaired concentration, emotional lability, increased appetite, sleep disorder and depression.^[Ref]

Respiratory

Respiratory side effects have included asthma.^[Ref]

Dermatologic

Dermatologic side effects have included pruritus. Alopecia has been reported during postmarketing experience.^[Ref]

Endocrine

Endocrine side effects have included increased sweating.^[Ref]

Genitourinary

Genitourinary side effects have included frequent micturition, polyuria, urinary tract infection, ovarian cyst, miscarriage, dysmenorrhea, and menorrhagia.^[Ref]

Renal

Renal side effects have included renal pain and albuminuria.^[Ref]

General

Side effects affecting the body as a whole have included accidental trauma (3% vs. 2% for placebo) and leg pain (1% vs. less than 1% for placebo). Other effects, regardless of causality, have included pain and facial edema.^[Ref]

Frequently asked questions

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