Note: This document contains side effect information about minocycline topical. Some dosage forms listed on this page may not apply to the brand name Zilxi.
Applies to minocycline topical: subgingival powder. Other dosage forms:
- topical application foam
Serious side effects of Zilxi
Along with its needed effects, minocycline topical (the active ingredient contained in Zilxi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking minocycline topical:
More common
- Bleeding from the gums
- chills
- dental pain
- fever
- pain, redness, and swelling in the mouth
- problems with teeth
- redness or swelling of the gums
- toothache
Less common
- Bad taste in the mouth
- discharge from the gums
- foul breath odor
- painful sores in the mouth
- problems in the lining of the mouth
Other side effects of Zilxi
Some side effects of minocycline topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Headache
Less common
- Acid or sour stomach
- belching
- cough
- heartburn
- increased sensitivity to sunlight
- indigestion
- pain
- pain in the joints or muscles
- runny nose
- sneezing
- sore throat
- stomach discomfort, upset, or pain
For Healthcare Professionals
Applies to minocycline topical: mucous membrane insert, topical foam.
General
Minocycline topical (the active ingredient contained in Zilxi) powder is intended for local application only. Systemic effects from the absorption of small amounts of the drug are unlikely.[Ref]
Other
Other side effects have included headache (9%) and pain (4.3%).[Ref]
Dermatologic
Dermatologic side effects have included stomatitis (6.4%), mouth ulceration (5%), and mucous membrane disorder (3.3%).[Ref]
Gastrointestinal
Gastrointestinal side effects have included dyspepsia (4%).[Ref]
Local
Local side effects have included periodontitis (16.3%), tooth disorder (12.3%), tooth caries (9.9%), dental pain (9.9%), gingivitis (9.2%), pharyngitis (4.3%), and dental infection (3.8%).[Ref]
Immunologic
Immunologic side effects have included flu syndrome (5%) and infection (7.6%).[Ref]
