Applies to ziv-aflibercept: intravenous solution.
Serious side effects of Ziv-aflibercept
Along with its needed effects, ziv-aflibercept may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking ziv-aflibercept:
More common
- Anxiety
- black, tarry stools
- bladder pain
- bleeding gums
- blood in the urine or stools
- bloody nose
- blurred vision
- chest pain
- confusion
- cough or hoarseness
- decreased urination
- difficult, burning, or painful urination
- dizziness or lightheadedness
- dry mouth
- excessive thirst
- fainting
- fever or chills
- frequent urge to urinate
- headache
- hoarseness
- lower back or side pain
- nervousness
- pain or swelling around the rectum
- pale skin
- pinpoint red spots on the skin
- pounding in the ears
- slow or fast heartbeat
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- sudden shortness of breath or troubled breathing
- sunken eyes
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- voice changes
- wrinkled skin
Less common
- Pains in the chest, groin, or legs, especially calves of the legs
- severe headaches of sudden onset
- sudden loss of coordination
- sudden onset of shortness of breath for no apparent reason
- sudden onset of slurred speech
- sudden vision changes
- troubled breathing
Rare
- Heartburn
- indigestion
- nausea
- severe abdominal or stomach pain, cramping, or burning
- vomiting of material that looks like coffee grounds, severe and continuing
Incidence not known
- Dilated neck veins
- extreme fatigue
- irregular breathing
- irregular heartbeat
- swelling of the face, fingers, feet, or lower legs
- tightness in the chest
- weight gain
Other side effects of Ziv-aflibercept
Some side effects of ziv-aflibercept may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Abdominal or stomach pain
- decreased appetite
- diarrhea
- lack or loss of strength
- redness, swelling, or pain of the skin
- runny nose
- scaling of the skin on the hands and feet
- swelling or inflammation of the mouth
- tingling of the hands and feet
- ulceration of the skin
Incidence not known
- Heavy jaw feeling
- loosening of a tooth
- pain, swelling, or numbness in the mouth or jaw
For Healthcare Professionals
Applies to ziv-aflibercept: intravenous solution.
Cardiovascular
Very common (10% or more): Hypertension (41%)
Common (1% to 10%): Arterial thromboembolic events (ATE) (e.g., transient ischemic attack, cerebrovascular accident, angina pectoris)
Postmarketing reports: Cardiac failure, ejection fraction decreased[Ref]
Dermatologic
Very common (10% or more): Palmar-plantar erythrodysesthesia syndrome (11%)
Common (1% to 10%): Skin hyperpigmentation[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (69%), stomatitis (50%), abdominal pain (27%), abdominal pain upper (11%)
Common (1% to 10%): Fistulas (anal, enterovesical, enterocutaneous, colovaginal, intestinal sites), dehydration, oropharyngeal pain, hemorrhoids, rectal hemorrhage, proctalgia
Uncommon (0.1% to 1%): GI hemorrhage, toothache[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection
Hematologic
Very common (10% or more): Leukopenia (78%), neutropenia (67%), thrombocytopenia (35%), hemorrhage (38%)[Ref]
Hypersensitivity
Uncommon (0.1% to 1%): Hypersensitivity[Ref]
Immunologic
Very common (10% or more): Infections (46%)
Common (1% to 10%): Immunogenicity[Ref]
Metabolic
Very common (10% or more): Anorexia (32%), weight loss (32%)
Postmarketing reports: Osteonecrosis of the jaw[Ref]
Nervous system
Very common (10% or more): Headache (22%)
Uncommon (0.1% to 1%): Reversible posterior leukoencephalopathy syndrome (RPLS)[Ref]
Other
Very common (10% or more): Fatigue (48%), dysphonia (25%), asthenia (18%)
Uncommon (0.1% to 1%): Compromised wound healing[Ref]
Renal
Very common (10% or more): Proteinuria (62%), serum creatinine increased (23%)[Ref]
Respiratory
Very common (10% or more): Epistaxis (28%), dyspnea (12%)
Common (1% to 10%): Rhinorrhea, nasopharyngitis[Ref]
Hepatic
Very common (10% or more): AST increased (62%), ALT increased (50%)[Ref]
