Applies to abemaciclib: oral tablets.

Side effects include:

Adverse effects reported in ≥20% of patients: Diarrhea, neutropenia, nausea, abdominal pain, infections, fatigue, anemia, leukopenia, decreased appetite, vomiting, headache, alopecia, thrombocytopenia.

For Healthcare Professionals

Applies to abemaciclib: oral tablet.

General

The most common adverse reactions reported (20% or greater incidence) were increased creatinine (98%), decreased white blood cell count (91%), diarrhea (90%), decreased neutrophil count (88%), anemia (84%), fatigue/asthenia (65%), nausea (64%), decreased lymphocyte count (63%), decreased platelet count (53%), neutropenia (46%), decreased appetite (45%), infections (43%), increased ALT (41%), abdominal pain (39%), increased AST (37%), vomiting (35%), leukopenia (28%), and thrombocytopenia (20%).^[Ref]

Renal

Very common (10% or more): Increased creatinine (98%)^[Ref]

Hematologic

Very common (10% or more): Decreased white blood cell count (91%), decreased neutrophil count (88%), anemia (84%), decreased lymphocyte count (63%), decreased platelet count (53%), neutropenia (46%), leukopenia (28%), thrombocytopenia (20%)

Common (1% to 10%): Febrile neutropenia, lymphopenia

Frequency not reported: Neutropenic sepsis^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (85%), nausea (64%), abdominal pain (39%), vomiting (28%), constipation (17%), stomatitis (15%), dry mouth (14%)^[Ref]

Other

Very common (10% or more): Fatigue/asthenia (65%), infections (43%), peripheral edema (12%), pyrexia (11%)^[Ref]

Metabolic

Very common (10% or more): Decreased appetite (27%), decreased weight (14%), dehydration (10%)^[Ref]

Hepatic

Very common (10% or more): Increased ALT (41%), increased AST (37%)^[Ref]

Respiratory

Very common (10% or more): Cough (19%)

Common (1% to 10%): Interstitial lung disease, pneumonitis^[Ref]

Nervous system

Very common (10% or more): Headache (20%), dysgeusia (14%), dizziness (13%)^[Ref]

Dermatologic

Very common (10% or more): Alopecia (21%), pruritus (14%), rash (13%)^[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (15%)^[Ref]

Cardiovascular

Common (1% to 10%): Venous thromboembolic events^[Ref]

Immunologic

Very common (10% or more): Infections (44%)