Note: This document contains side effect information about perindopril. Some dosage forms listed on this page may not apply to the brand name Aceon.
Summary
Common side effects of Aceon include: cough. Continue reading for a comprehensive list of adverse effects.
Applies to perindopril: oral tablets.
Warning
- May cause fetal and neonatal morbidity and mortality if used during pregnancy.1 42 43 (See Fetal/Neonatal Morbidity and Mortality under Cautions.)
- If pregnancy is detected, discontinue perindopril as soon as possible.1 43
Side effects include:
Cough, proteinuria, palpitation, sinusitis, viral infection, dyspepsia, fever, upper extremity pain, hypertonia.
Dizziness reported at a rate similar to that with placebo, but incidence increases with increased dosage, suggesting causal relation to the drug.
For Healthcare Professionals
Applies to perindopril: oral tablet.
General
The most common adverse events were cough, dizziness, and back pain.[Ref]
Respiratory
Very common (10% or more): Cough (up to 12%)
Common (1% to 10%): Dyspnea, epistaxis
Uncommon (0.1% to 1%): Bronchospasm
Very rare (less than 0.01%): Eosinophilic pneumonia, rhinitis[Ref]
Nervous system
Common (1% to 10%): Dizziness, headache, paresthesia, vertigo, tinnitus, dysgeusia, drowsiness
Uncommon (0.1% to 1%): Somnolence, syncope
Very rare (less than 0.01%): Stroke[Ref]
Gastrointestinal
Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting
Uncommon (0.1% to 1%): Dry mouth
Very rare (less than 0.01%): Pancreatitis
Postmarketing reports: Acute pancreatitis[Ref]
Cardiovascular
Common (1% to 10%): Hypotension, palpitations, vasculitis, flushing, impaired peripheral circulation
Uncommon (0.1% to 1%): Tachycardia
Rare (0.01% to 0.1%): Sudden cardiac arrest
Very rare (less than 0.01%): Angina pectoris, arrhythmia, myocardial infarction[Ref]
Dermatologic
Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Urticaria, angioedema, photosensitivity reactions, pemphigoid, hyperhidrosis, eczema, sweating
Very rare (less than 0.01%): Erythema multiforme
Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis[Ref]
Other
Common (1% to 10%): Asthenia, discomfort on exertion
Uncommon (0.1% to 1%): Chest pain, malaise, edema peripheral, pyrexia, fall, atypical chest pain
Postmarketing reports: Serositis[Ref]
Musculoskeletal
Common (1% to 10%): Muscle cramps, back pain
Uncommon (0.1% to 1%): Arthralgia, myalgia[Ref]
Hepatic
Common (1% to 10%): ALT increased
Uncommon (0.1% to 1%): AST increased
Rare (0.01% to 0.1%): Blood bilirubin increased, hepatic enzyme increased
Very rare (less than 0.01%): Hepatitis
Postmarketing reports: Hepatic failure, jaundice[Ref]
Ocular
Common (1% to 10%): Visual disturbances[Ref]
Renal
Uncommon (0.1% to 1%): Renal insufficiency, blood urea increased, blood creatinine increased
Very rare (less than 0.01%): Acute renal failure
Postmarketing reports: Nephritis[Ref]
Metabolic
Uncommon (0.1% to 1%): Hypoglycemia, hyperkalemia, hyponatremia
Postmarketing reports: Symptomatic hyponatremia[Ref]
Hematologic
Uncommon (0.1% to 1%): Eosinophilia, leukopenia/neutropenia
Very rare (less than 0.01%): Agranulocytosis or pancytopenia, hemoglobin decreased and hematocrit decreased, hemolytic anemia in patients with a congenital deficiency of glucose-6-phosphate dehydrogenase, thrombocytopenia, unexplained change in prothrombin ratio
Postmarketing reports: Anemia, leukocytosis, elevated erythrocyte sedimentation rate[Ref]
Psychiatric
Uncommon (0.1% to 1%): Mood disturbances, sleep disorder
Very rare (less than 0.01%): Confusion, depression, hallucinations[Ref]
Genitourinary
Uncommon (0.1% to 1%): Erectile dysfunction[Ref]
Immunologic
Postmarketing reports: Positive antinuclear antibody[Ref]
