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Home > Drugs > Peripheral opioid receptor antagonists > Alvimopan > Alvimopan Side Effects
Peripheral opioid receptor antagonists

Alvimopan Side Effects

Summary

More frequently reported side effects include: constipation. Continue reading for a comprehensive list of adverse effects.

Applies to alvimopan: oral capsule.

Warning

Oral route (Capsule)

There was a greater incidence of myocardial infarction in alvimopan-treated patients compared to placebo-treated patients in a 12-month clinical trial, although a causal relationship has not been established. In short-term trials with Alvimopan, no increased risk of myocardial infarction was observed. Because of the potential risk of myocardial infarction with long-term use, alvimopan is available only through a restricted program for short-term use (15 doses) under a Risk Evaluation and Mitigation Strategy (REMS) called the Alvimopan REMS Program.

Serious side effects of Alvimopan

Along with its needed effects, alvimopan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alvimopan:

More common

  • Acid or sour stomach
  • belching
  • bloated
  • convulsions
  • decreased urine
  • difficulty having a bowel movement (stool)
  • dry mouth
  • excess air or gas in stomach or intestines
  • full feeling
  • heartburn
  • increased thirst
  • indigestion
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in hands, feet, or lips
  • pale skin
  • passing gas
  • shortness of breath
  • stomach discomfort, upset, or pain
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Decrease in frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • painful urination

Other side effects of Alvimopan

Some side effects of alvimopan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Back pain

For Healthcare Professionals

Applies to alvimopan: oral capsule.

General

The most commonly reported side effect included dyspepsia.[Ref]

Gastrointestinal

Common (1% to 10%): Dyspepsia[Ref]

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