Applies to amlodipine / benazepril: oral capsule.
Warning
Oral route (Capsule)
Discontinue amlodipine besylate/benazepril hydrochloride as soon as possible if pregnancy is detected. This drug can cause injury and death to the fetus.
Serious side effects
Along with its needed effects, amlodipine / benazepril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking amlodipine / benazepril:
Less common
- Confusion
- dizziness, lightheadedness, or fainting
- fast or irregular heartbeat
- nervousness
- numbness or tingling in the hands, feet, or lips
- swelling of the ankles, feet, or lower legs
- weakness or heaviness of the legs
Rare
- Bleeding gums
- chills
- fever
- nausea or vomiting
- nosebleeds
- pale skin
- sores, ulcers, or white spots on the lips, tongue, or inside the mouth
- stomach pain or bloating with fever, nausea, or vomiting
- swelling of the face, mouth, hands, or feet
- trouble with swallowing or breathing (sudden) or hoarseness
- unusual bleeding or bruising
- unusual tiredness or weakness
- yellow eyes or skin
Incidence not known
- Chest pain
- heartburn
- pain or burning in the throat
Other side effects
Some side effects of amlodipine / benazepril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Cough (dry and continuous)
- feeling of warmth
- redness of the face, neck, arms, and occasionally upper chest
- sleepiness
Incidence not known
- Belching
- blistering, crusting, irritation, itching, or reddening of the skin
- body aches or pain
- cracked, dry, or scaly skin
- decreased interest in sexual intercourse
- difficulty having a bowel movement
- frequent urination
- inability to have or keep an erection
- increased volume of pale, dilute urine
- indigestion
- lack or loss of strength
- loss in sexual ability, desire, drive, or performance
- muscle or bone pain
- shakiness in the legs, arms, hands, or feet
- stomach discomfort or upset
- sudden sweating
- swelling
- tender, swollen glands in the neck
- trembling or shaking of the hands or feet
- trouble with sleeping
- voice changes
For Healthcare Professionals
Applies to amlodipine / benazepril: oral capsule.
General
The most common side effects were cough, headache, dizziness, and edema.[Ref]
Nervous system
Common (1% to 10%): Headache, dizziness
Frequency not reported: Tremor
Amlodipine:
Common (1% to 10%): Headache, dizziness
Postmarketing reports: Dysgeusia, hypoesthesia, paresthesia, syncope, peripheral neuropathy, hypertonia
Benazepril:
Common (1% to 10%): Headache, dizziness
Postmarketing reports: Paresthesia, dysgeusia[Ref]
Respiratory
Common (1% to 10%): Cough
Frequency not reported: Pharyngitis
Amlodipine:
Uncommon (0.1% to 1%): Cough
Postmarketing reports: Rhinitis
Benazepril:
Common (1% to 10%): Cough[Ref]
Other
Common (1% to 10%): Edema
Frequency not reported: Asthenia, fatigue
Amlodipine:
Common (1% to 10%): Edema
Postmarketing reports: Malaise
Benazepril:
Uncommon (0.1% to 1%): Edema[Ref]
Amlodipine-induced peripheral edema is dose dependent. Benazepril reduces the incidence of edema when added to amlodipine.[Ref]
Genitourinary
Frequency not reported: Impotence, polyuria
Amlodipine:
Postmarketing reports: Micturition disorder, nocturia, erectile dysfunction[Ref]
Gastrointestinal
Frequency not reported: Dry mouth, nausea, abdominal pain, constipation, diarrhea, dyspepsia, esophagitis
Amlodipine:
Postmarketing reports: Gingival hyperplasia, gastritis[Ref]
Musculoskeletal
Frequency not reported: Back pain, musculoskeletal pain, cramps, muscle cramps
Amlodipine:
Postmarketing reports: Muscle spasms, arthralgia
Benazepril:
Postmarketing reports: Arthralgia, arthritis, myalgia[Ref]
Dermatologic
Frequency not reported: Rash, skin nodule, dermatitis
Amlodipine:
Postmarketing reports: Hyperhidrosis, pruritus, skin discoloration, urticaria, erythema multiform
Benazepril:
Postmarketing reports: Stevens-Johnson syndrome, pemphigus, pruritus, photosensitivity reaction[Ref]
Psychiatric
Frequency not reported: Insomnia, nervousness, anxiety, libido decreased[Ref]
Cardiovascular
Frequency not reported: Flushing, hot flashes
Amlodipine:
Postmarketing reports: Tachycardia, hypotension, vasculitis
Benazepril:
Postmarketing reports: Orthostatic symptoms, hypotension, angina pectoris, arrhythmia[Ref]
Ocular
Amlodipine:
Postmarketing reports: Visual impairment, diplopia
Benazepril:
Postmarketing reports: Impaired vision[Ref]
Metabolic
Frequency not reported: Hypokalemia
Amlodipine:
Postmarketing reports: Hyperglycemia, weight decrease or gain[Ref]
Immunologic
Amlodipine:
Postmarketing reports: Allergic reaction[Ref]
Renal
Benazepril
Postmarketing reports: Serum creatinine increased, BUN increased, renal impairment[Ref]
Hematologic
Frequency not reported: Neutropenia
Amlodipine:
Postmarketing reports: Leucocytopenia
Benazepril:
Postmarketing reports: Hemolytic anemia, thrombocytopenia, agranulocytosis, neutropenia[Ref]
Hepatic
Amlodipine:
Postmarketing reports: Jaundice, hepatic enzyme elevations
Benazepril:
Postmarketing reports: Pancreatitis[Ref]
