Note: This document contains side effect information about candesartan / hydrochlorothiazide. Some dosage forms listed on this page may not apply to the brand name Atacand HCT.
Applies to candesartan / hydrochlorothiazide: oral tablet.
Warning
Oral route (Tablet)
When pregnancy is detected, discontinue candesartan cilexetil/hydrochlorothiazide as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus
Serious side effects of Atacand HCT
Along with its needed effects, candesartan / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking candesartan / hydrochlorothiazide:
Less common
- Cough
- dizziness
- dryness of the mouth
- fever
- increased thirst
- irregular heartbeat
- lightheadedness
- muscle cramps
- nausea
- sore throat
- unusual tiredness
- vomiting
- weak pulse
- weakness
Rare
- Arm pain
- chest pain or tightness
- fast heartbeat
- large, hive like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- trouble breathing
Incidence not known
- Black, tarry stools
- chills
- confusion
- lower back or side pain
- nervousness
- numbness or tingling in the hands, feet, or lips
- painful or difficult urination
- pale skin
- persistent non-healing sore
- pink growth
- reddish patch or irritated area
- shiny bump
- sores, ulcers, or white spots in the mouth or on the lips
- stomach pain
- swelling of the face, ankles, or hands
- unusual bleeding or bruising
- weakness or heaviness of the legs
- white, yellow or waxy scar-like area
Other side effects of Atacand HCT
Some side effects of candesartan / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Back pain
- diarrhea
- headache
- joint pain
- loss of appetite
- muscle aches and pains
- runny nose
- sneezing
- sweating
- trouble sleeping
Incidence not known
- Blistering, peeling, loosening of skin
- decreased interest in sexual intercourse
- hair loss, thinning of the hair
- hives or welts, itching, skin rash
- inability to have or keep an erection
- increased sensitivity of the skin to sunlight
- loss in sexual ability, desire, drive, or performance
- redness of the skin
- redness or other discoloration of the skin
- red irritated eyes
- red skin lesions, often with a purple center
- severe sunburn
For Healthcare Professionals
Applies to candesartan / hydrochlorothiazide: oral tablet.
Respiratory
Common (1% to 10%): Upper respiratory tract infection, respiratory infection, bronchitis, pharyngitis, sinusitis, nasopharyngitis, cough
Candesartan:
Frequency not reported: Cough, rhinitis
Hydrochlorothiazide:
Frequency not reported: Pneumonitis, pulmonary edema[Ref]
Metabolic
Common (1% to 10%): Hypokalemia, dyslipidemia
Uncommon (0.1% to 1%): Hyperkalemia
Candesartan:
Very rare (less than 0.01%): Hyponatremia, hyperkalemia
Hydrochlorothiazide:
Frequency not reported: Anorexia, loss of appetite, hyperglycemia, hyperuricemia, hyponatremia, hypokalemia, cholesterol increased, triglycerides increased[Ref]
Gastrointestinal
Common (1% to 10%): Abdominal pain, nausea
Uncommon (0.1% to 1%): Vomiting
Candesartan:
Frequency not reported: Diarrhea
Hydrochlorothiazide:
Frequency not reported: Gastric irritation, diarrhea, constipation
Postmarketing reports: Sialadenitis, cramping[Ref]
Other
Common (1% to 10%): Influenza-like symptoms, inflicted injury
Frequency not reported: Fatigue
Candesartan:
Frequency not reported: Peripheral edema
Hydrochlorothiazide:
Frequency not reported: Fever, weakness, vertigo[Ref]
Nervous system
Common (1% to 10%): Dizziness, headache
Candesartan:
Postmarketing reports: Somnolence
Hydrochlorothiazide:
Frequency not reported: Lightheadedness, paresthesia[Ref]
Cardiovascular
Common (1% to 10%): Tachycardia
Uncommon (0.1% to 1%): Atrioventricular block
Candesartan:
Postmarketing reports: Palpitations
Hydrochlorothiazide:
Frequency not reported: Vasculitis, postural hypotension, cardiac arrhythmias[Ref]
Musculoskeletal
Common (1% to 10%): Back pain
Postmarketing reports: Myalgia
Candesartan:
Postmarketing reports: Rhabdomyolysis
Hydrochlorothiazide:
Frequency not reported: Muscle spasm[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection
Hydrochlorothiazide:
Frequency not reported: Glycosuria
Postmarketing reports: Impotence[Ref]
Dermatologic
Candesartan:
Very rare (less than 0.01%): Angioedema, urticaria, pruritus, rash
Hydrochlorothiazide:
Frequency not reported: Photosensitivity reactions, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, urticaria, cutaneous vasculitis, toxic epidermal necrolysis
Postmarketing reports: Purpura, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, alopecia[Ref]
Hematologic
Candesartan:
Very rare (less than 0.01%): Leucopenia, neutropenia, agranulocytosis
Hydrochlorothiazide:
Frequency not reported: Leucopenia, neutropenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bone marrow depression[Ref]
Hepatic
Candesartan:
Very rare (less than 0.01%): Liver enzymes increased, abnormal hepatic function, hepatitis
Hydrochlorothiazide:
Frequency not reported: Intrahepatic cholestatic jaundice, pancreatitis[Ref]
Renal
Candesartan:
Very rare (less than 0.01%): Renal impairment, renal failure
Hydrochlorothiazide:
Frequency not reported: BUN increased, serum creatinine increased, renal dysfunction, interstitial nephritis[Ref]
Psychiatric
Candesartan:
Postmarketing reports: Agitation, anxiety, depression, insomnia, nervousness, sleep disorder, nightmare
Hydrochlorothiazide:
Frequency not reported: Restlessness, sleep disturbances, depression[Ref]
Ocular
Hydrochlorothiazide:
Frequency not reported: Transient blurred vision, acute myopia, acute angle-closure glaucoma, xanthopsia[Ref]
Immunologic
Hydrochlorothiazide:
Frequency not reported: Anaphylactic reactions[Ref]
