Note: This document contains side effect information about encorafenib. Some dosage forms listed on this page may not apply to the brand name Braftovi.
Applies to encorafenib: oral capsule.
Serious side effects of Braftovi
Along with its needed effects, encorafenib (the active ingredient contained in Braftovi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking encorafenib:
More common
- Bleeding gums
- bloating
- chills
- constipation
- coughing up blood
- dark urine
- difficulty in breathing or swallowing
- dizziness
- fast heartbeat
- fever
- headache
- hives, itching, skin rash
- hoarseness
- increased menstrual flow or vaginal bleeding
- indigestion
- irritation
- joint pain, stiffness, or swelling
- loss of appetite
- nausea
- nosebleed
- pains in the stomach, side, or abdomen, possibly radiating to the back
- partial or slight paralysis of the face
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark-brown urine
- redness, swelling, or pain of the skin
- scaling of the skin on the hands and feet
- swelling of the eyelids, face, lips, hands, or feet
- thickening of the skin
- tightness in the chest
- tingling of the hands and feet
- ulceration of the skin
- unusual tiredness or weakness
- vomiting
- yellow eyes or skin
Rare
- Black, tarry stools
- bloody stools
- vomiting of blood or material that looks like coffee grounds
Other side effects of Braftovi
Some side effects of encorafenib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Back pain
- burning, numbness, tingling, or painful sensations
- change in taste
- difficulty in moving
- dry skin
- hair loss, thinning of hair
- loss of taste
- muscular pain, tenderness, wasting, or weakness
- pain in the arms or legs
- stomach pain
- unsteadiness or awkwardness
- weakness in the arms, hands, legs, or feet
For Healthcare Professionals
Applies to encorafenib: oral capsule.
Hematologic
Very common (10% or more): Anemia (36%), hemorrhage (19%), leukopenia (13%), lymphopenia (13%), neutropenia (13%)[Ref]
Hypersensitivity
Common (1% to 10%): Hypersensitivity[Ref]
Musculoskeletal
Very common (10% or more): Arthralgia (46%), myopathy (23%), pain in extremity (11%), myalgia, back pain[Ref]
Ocular
Common (1% to 10%): Uveitis (e.g., iritis, iridocyclitis), visual impairment[Ref]
Metabolic
Very common (10% or more): Increased alkaline phosphatase (35%), hyperglycemia (28%), hypermagnesemia (26%), hyponatremia (18%), decreased appetite[Ref]
Hepatic
Very common (10% or more): Increased gamma glutamyl transferase (45%), increased ALT (29%), increased AST (27%)[Ref]
Oncologic
Common (1% to 10%): New primary melanoma, cutaneous squamous cell carcinoma (cuSCC) including keratoacanthoma (KA), basal cell carcinoma[Ref]
Other
Very common (10% or more): Pyrexia (30%), fatigue, peripheral edema[Ref]
Nervous system
Very common (10% or more): Fatigue (46%), headache (22%), dizziness (15%), peripheral neuropathy (12%), intracranial hemorrhage in the setting of new or progressive brain metastases (sometimes fatal)
Common (1% to 10%): Facial paresis, dysgeusia[Ref]
Renal
Very common (10% or more): Creatinine increased (93%)
Common (1% to 10%): Renal failure[Ref]
Cardiovascular
Very common (10% or more): Hypertension (e.g., pulmonary embolism, deep vein thrombosis, embolism, thrombophlebitis, thrombophlebitis superficial, thrombosis)
Uncommon (0.1% to 1%): QTc interval prolongation[Ref]
Dermatologic
Very common (10% or more): Rash (53%), hyperkeratosis (49%), alopecia (38%), dry skin (26%), pruritus (21%), skin papilloma (e.g., keratoacanthoma, squamous cell carcinoma, lip squamous cell carcinoma, squamous cell carcinoma of skin), melanocytic nevus
Common (1% to 10%): Panniculitis, new primary melanoma, basal cell carcinoma, skin papilloma, dermatitis acneiform, skin exfoliation, photosensitivity, panniculitis[Ref]
Gastrointestinal
Very common (10% or more): Nausea (41%), vomiting (30%), abdominal pain (28%), constipation (22%), diarrhea
Common (1% to 10%): GI hemorrhage (including rectal hemorrhage), hematochezia, hemorrhoidal hemorrhage, pancreatitis, colitis
Uncommon (0.1% to 1%): Pancreatitis[Ref]
Psychiatric
Very common (10% or more): Insomnia[Ref]
