Summary of Use during Lactation

Leucovorin (folinic acid) and its levo- isomer, levoleucovorin, are folic acid derivatives and are normal components of breastmilk.[1] Because leucovorin and levoleucovorin are used as therapeutic agents with potentially toxic drugs such as fluorouracil or methotrexate, the LactMed record of the drug it is used with should be consulted.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.

Su Y, Mao Y, Tian F, et al. Profile of folate in breast milk from Chinese women over 1-400 days postpartum. Nutrients. 2022;14:2962. [PMC free article: PMC9319857] [PubMed: 35889919]

Substance Name

Leucovorin

CAS Registry Number

58-05-9

Drug Class

Breast Feeding

Lactation

Milk, Human

Antidotes

Vitamin B Complex

Vitamins