Summary
Commonly reported side effects of brodalumab include: infection. Continue reading for a comprehensive list of adverse effects.
Applies to brodalumab: subcutaneous solution.
Warning
Subcutaneous route (Solution)
Suicidal ideation and behavior, including completed suicides, have occurred with brodalumab. Weigh potential risks and benefits in each patient prior to initiation, and advise patients and caregivers to seek medical attention for new or worsening depression, anxiety, or other mood changes. Refer patients with new or worsening suicidal ideation and behavior to a mental health professional. Brodalumab is only available through a restricted program called the Siliq REMS Program.
Serious side effects of Brodalumab
Along with its needed effects, brodalumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking brodalumab:
Less common
- Black, tarry stools
- chills
- cough
- diarrhea
- fever
- general feeling of discomfort or illness
- headache
- joint pain
- loss of appetite
- lower back or side pain
- muscle aches and pains
- nausea
- painful or difficult urination
- pale skin
- runny nose
- shivering
- sore throat
- sweating
- trouble sleeping
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting
Incidence not known
- Changes in behavior
- discouragement
- feeling sad or empty
- irritability
- lack of appetite
- loss of interest or pleasure
- thoughts of killing oneself
- trouble concentrating
- trouble sleeping
Other side effects of Brodalumab
Some side effects of brodalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Difficulty with moving
- muscle pain or stiffness
- pain in the joints
- pain, redness, burning, or itching at the injection site
For Healthcare Professionals
Applies to brodalumab: subcutaneous solution.
Gastrointestinal
Common (1% to 10%): Diarrhea, oropharyngeal pain, nausea[Ref]
Hematologic
Common (1% to 10%): Neutropenia[Ref]
Genitourinary
Frequency not reported: Urinary tract infection[Ref]
Other
Common (1% to 10%): Fatigue[Ref]
Immunologic
Common (1% to 10%): Influenza, tinea infections (i.e., tinea pedis, tinea versicolor, tinea cruris), immunogenicity
Uncommon (0.1% to 1%): Candida infections (i.e., oral, genital, esophageal)[Ref]
Local
Common (1% to 10%): Injection site reactions (i.e., pain, erythema, bruising, hemorrhage, pruritus)[Ref]
Musculoskeletal
Common (1% to 10%): Arthralgia, myalgia[Ref]
Nervous system
Common (1% to 10%): Headache[Ref]
Ocular
Uncommon (0.1% to 1%): Conjunctivitis[Ref]
Respiratory
Frequency not reported: Nasopharyngitis, upper respiratory tract infection, pharyngitis, bronchitis[Ref]
Psychiatric
Uncommon (0.1% to 1%): Suicidal ideation or behavior[Ref]
