Note: This document contains side effect information about zanubrutinib. Some dosage forms listed on this page may not apply to the brand name Brukinsa.

Applies to zanubrutinib: oral capsules.

Side effects include:

Adverse effects (≥30%): decreased neutrophil count, decreased platelet count, upper respiratory tract infection,  hemorrhage,   musculoskeletal pain.

For Healthcare Professionals

Applies to zanubrutinib: oral capsule.

Hematologic

Very common (10% or more): All grades neutropenia (up to 56%), all grades thrombocytopenia (up to 45%) , hemorrhage (up to 32%), all grades anemia (up to 28%) , all grades leukopenia (25%)

Common (1% to 10%): Grade 3 or 4 anemia, Grade 3 or 4 leukopenia, Grade 3 or 4 thrombocytopenia^[Ref]

Immunologic

Very common (10% or more): Grade 3 or higher infection (23%)^[Ref]

Musculoskeletal

Very common (10% or more): Musculoskeletal pain (e.g., musculoskeletal pain, musculoskeletal discomfort, myalgia, back pain, arthralgia, arthritis) (up to 45%), muscle spasms (10%)^[Ref]

Metabolic

Very common (10% or more): Glucose increased (45%), blood uric acid increased (up to 29%), hypokalemia (14%), calcium decreased (27%), hyperkalemia (24%), hypophosphatemia (20%)

Genitourinary

Very common (10% or more): Urinary tract infection (up to 15%)^[Ref]

Hepatic

Very common (10% or more): ALT increased (28%), bilirubin increased (up to 24%)

Common (1% to 10%): Hepatitis B reactivation^[Ref]

Oncologic

Very common (10% or more): Second primary malignancies (13%)^[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (up to 44%), pneumonia (up to 22%), cough (up to 21%)^[Ref]

Cardiovascular

Very common (10% or more): Hypertension (12%)

Common (1% to 10%): Atrial fibrillation, atrial flutter^[Ref]

Dermatologic

Very common (10% or more): Rash (up to 30%), bruising (up to 20%), pruritus (11%)^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 23%), constipation (up to 16%), nausea (18%)

Uncommon (0.1% to 1%): Gastrointestinal hemorrhage^[Ref]

General

The most common adverse events were neutropenia, thrombocytopenia, upper respiratory tract infection, hemorrhage, rash, anemia and musculoskeletal pain.

Renal

Very common (10% or more): Creatinine increased (31%)

Other

Very common (10% or more): Fatigue (up to 15%), peripheral edema (12%), pyrexia (16%)

Common (1% to 10%): Asthenia

Nervous system

Very common (10% or more): Dizziness (11%)