Applies to cefoxitin: intravenous powder for solution, intravenous solution.
Serious side effects of Cefoxitin
Along with its needed effects, cefoxitin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking cefoxitin:
More common
- Changes in skin color
- pain
- swelling of the foot or leg
- tenderness
Rare
- Agitation
- coma
- confusion
- decreased urine output
- depression
- dizziness
- headache
- hostility
- irritability
- lethargy
- muscle twitching
- nausea
- rapid weight gain
- seizures
- stupor
- swelling of the face, ankles, or hands
- unusual tiredness or weakness
Incidence not known
- Abdominal or stomach cramps or tenderness
- back, leg, or stomach pains
- bleeding and bruising
- bleeding gums
- blistering, peeling, or loosening of the skin
- bloating
- bloody or cloudy urine
- bloody, black, or tarry stools
- chest pain
- chills
- clay-colored stools
- cloudy urine
- cough
- coughing up blood
- cracks in the skin
- dark urine
- decrease in urine output or decrease in urine-concentrating ability
- diarrhea
- diarrhea, watery and severe, which may also be bloody
- difficult or labored breathing
- difficult or painful urination
- difficulty with breathing, chewing, swallowing, or talking
- dizziness
- double vision
- drooping eyelids
- fast heartbeat
- feeling of discomfort
- fever
- general body swelling
- greatly decreased frequency of urination or amount of urine
- headache
- high fever
- hives
- increased menstrual flow or vaginal bleeding
- increased thirst
- inflammation of the joints
- itching
- itching of the vagina or genital area
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- loss of heat from the body
- muscle aches
- muscle weakness
- nosebleeds
- pain during sexual intercourse
- pale skin
- paralysis
- prolonged bleeding from cuts
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rash
- red or black, tarry stools
- red or dark brown urine
- red skin lesions, often with a purple center
- red, irritated eyes
- red, swollen skin
- scaly skin
- severe tiredness
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- sudden decrease in the amount of urine
- swelling of the feet or lower legs
- swollen lymph glands
- swollen or painful glands
- thick, white vaginal discharge with no odor or with a mild odor
- tightness in the chest
- troubled breathing with exertion
- unexplained bleeding or bruising
- unpleasant breath odor
- unusual bleeding or bruising
- unusual weight loss
- vomiting
- vomiting of blood
- wheezing
- yellowing of the eyes or skin
Other side effects of Cefoxitin
Some side effects of cefoxitin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Red streaks on the skin
- swelling, tenderness, or pain at the injection site
Incidence not known
- Hives or welts
- redness of the skin
For Healthcare Professionals
Applies to cefoxitin: injectable powder for injection, intravenous powder for injection, intravenous solution.
Local
Common (1% to 10%): Induration, pain, pain in the infused vein, phlebitis, tenderness, thrombophlebitis, vein erythema, vein exudates, vein induration[Ref]
Phlebitis and thrombophlebitis occurred with IV administration.
Induration, pain, and tenderness occurred in of patients who received IM administration.[Ref]
Dermatologic
Common (1% to 10%): Maculopapular rash, rash/skin rashes, urticaria
Frequency not reported: Acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme, exfoliative dermatitis, pruritus, severe cutaneous adverse reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]
Gastrointestinal
Rare (0.01% to 0.1%): Diarrhea, nausea, vomiting
Frequency not reported: Abdominal pain, colitis, pseudomembranous colitis[Ref]
Pseudomembranous colitis may occur during or after treatment.[Ref]
Hematologic
Frequency not reported: Agranulocytosis, anemia, aplastic anemia, bone marrow depression, eosinophilia, granulocytopenia, hemolytic anemia, leukocytosis, leukopenia, neutropenia, pancytopenia, positive direct Coombs test, prolonged prothrombin time, thrombocytopenia[Ref]
Renal
Rare (0.01% to 0.1%): Acute renal failure
Frequency not reported: Elevation in blood urea nitrogen (BUN), elevation in serum creatinine, interstitial nephritis, prerenal azotemia, renal dysfunction, toxic nephropathy[Ref]
Hepatic
Frequency not reported: Cholestasis, elevated bilirubin, jaundice, liver dysfunction, transient elevations in ALT/AST/serum alkaline phosphatase[Ref]
Cardiovascular
Frequency not reported: Flushing, hemorrhage, hypotension[Ref]
Hypersensitivity
Allergic reactions included anaphylaxis, angioedema, dyspnea, eosinophilia, fever, flushing, interstitial nephritis, pruritus, and skin reactions (e.g., exfoliative dermatitis, maculopapular rash, rash, toxic epidermal necrolysis, urticaria). Anaphylaxis rarely led to death.[Ref]
Frequency not reported: Anaphylaxis, angioedema, other allergic reactions[Ref]
Immunologic
Frequency not reported: Serum sickness-like reaction, superinfection[Ref]
Other
Frequency not reported: Death, fever[Ref]
Metabolic
Frequency not reported: False positive for urinary glucose, transient elevation in LDH[Ref]
Genitourinary
Frequency not reported: Vaginitis, vaginitis candidiasis[Ref]
Nervous system
Frequency not reported: Seizures[Ref]
Musculoskeletal
Frequency not reported: Myasthenia gravis exacerbation[Ref]
Respiratory
Frequency not reported: Dyspnea[Ref]
