Applies to chlorthalidone: oral tablet.

Serious side effects of Chlorthalidone

Along with its needed effects, chlorthalidone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlorthalidone:

Incidence not known

• Abdominal or stomach pain
• black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of the skin
• bloating
• blood in the urine or stools
• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chest pain
• chills
• clay-colored stools
• cold sweats
• confusion
• cough or hoarseness
• coughing up blood
• darkened urine
• diarrhea
• difficulty having a bowel movement (stool)
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• fast heartbeat
• fever
• flushed, dry skin
• fruit-like breath odor
• general feeling of tiredness or weakness
• headache
• increased hunger
• increased thirst
• increased urination
• indigestion
• itching or skin rash
• joint pain, stiffness, or swelling
• loss of appetite
• lower back or side pain
• nausea
• pain in the joints or muscles
• painful or difficult urination
• pains in the stomach, side, or abdomen, possibly radiating to the back
• pinpoint red spots on the skin
• red, irritated eyes
• red skin lesions, often with a purple center
• redness, soreness or itching skin
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• sores, welting, or blisters
• sugar in the urine
• sweating
• swelling of the feet or lower legs
• swollen glands
• tightness in the chest
• troubled breathing
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight loss
• vomiting
• vomiting of blood
• weight loss
• yellow eyes or skin

Other side effects of Chlorthalidone

Some side effects of chlorthalidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Cramping
• decreased interest in sexual intercourse
• feeling of constant movement of self or surroundings
• hives
• inability to have or keep an erection
• increased sensitivity of the skin to sunlight
• loss in sexual ability, desire, drive, or performance
• muscle spasm
• redness or other discoloration of the skin
• restlessness
• sensation of spinning
• severe sunburn
• weakness

For Healthcare Professionals

Applies to chlorthalidone: oral tablet.

Cardiovascular

Common (1% to 10%): Postural hypotension

Rare (less than 0.1%): Cardiac arrhythmias^[Ref]

Dermatologic

Common (1% to 10%): Urticaria, rash

Rare (less than 0.1%): Photosensitivity

Frequency not reported: Purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), Lyell's syndrome (toxic epidermal necrolysis)^[Ref]

Gastrointestinal

Common (1% to 10%): GI discomfort, anorexia

Rare (0.01% to 0.1%): Nausea, vomiting, upper abdominal pain, constipation, diarrhea

Very rare (less than 0.01%): Pancreatitis

Frequency not reported: Cramping^[Ref]

Genitourinary

Common (1% to 10%): Impotence

Frequency not reported: Glycosuria^[Ref]

Hematologic

Rare (less than 0.1%): Thrombocytopenia, leucopenia, agranulocytosis

eosinophilia

Frequency not reported: Aplastic anemia^[Ref]

Metabolic

Very common (10% or more): Hypokalemia, hyperuricemia, hyperlipidemia

Common (1% to 10%): Hyponatremia, hypomagnesemia, hyperglycemia

Uncommon (0.1% to 1%): Gout

Rare (0.01% to 0.1%): Hypercalcemia, inadequate control of diabetes mellitus

Very rare (less than 0.01%): Hypochloremic alkalosis^[Ref]

Hepatic

Rare (less than 0.1%): Intrahepatic cholestasis or jaundice^[Ref]

Hypersensitivity

Hypersensitivity reactions usually involve the skin (see DERMATOLOGIC).^[Ref]

Musculoskeletal

Frequency not reported: Muscle spasm^[Ref]

Nervous system

Common (1% to 10%): Dizziness

Rare (less than 0.1%): Paresthesia, headache

Frequency not reported: Vertigo^[Ref]

Other

Frequency not reported: Vertigo, weakness^[Ref]

Ocular

Rare (less than 0.1%): Visual impairment

Frequency not reported: Xanthopsia^[Ref]

Psychiatric

Frequency not reported: Restlessness^[Ref]

Respiratory

Very rare (less than 0.01%): Noncardiogenic pulmonary edema^[Ref]