Summary
Commonly reported side effects of colesevelam include: constipation. Other side effects include: dyspepsia. Continue reading for a comprehensive list of adverse effects.
Applies to colesevelam: oral powder for suspension, oral tablet.
Serious side effects of Colesevelam
Along with its needed effects, colesevelam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking colesevelam:
More common
- Acid or sour stomach
- belching
- bloating
- constipation
- fever
- headache
- heartburn
- indigestion
- muscle aches
- sore throat
- stomach pain or discomfort
- unusual tiredness or weakness
Less common
- Anxiety
- blurred vision
- body aches or pain
- chills
- cold sweats
- confusion
- cool, pale skin
- cough
- depression
- diarrhea
- difficulty in breathing
- difficulty in moving
- dizziness
- dry or sore throat
- ear congestion
- general feeling of discomfort or illness
- hoarseness
- increased hunger
- joint pain or swelling
- loss of appetite
- loss of consciousness
- loss of voice
- muscle pains, cramps, or stiffness
- nausea
- nervousness
- nightmares
- pounding in the ears
- seizures
- shakiness
- shivering
- slow or fast heartbeat
- slurred speech
- sneezing
- stuffy or runny nose
- sweating
- tender, swollen glands in the neck
- trouble with sleeping
- trouble with swallowing
- voice changes
- vomiting
Incidence not known
- Bleeding after defecation
- dark urine
- pain or discomfort in the chest
- pains in the stomach, side, or abdomen, possibly radiating to the back
- swelling of the stomach area
- unable to swallow saliva
- uncomfortable swelling around the anus
- yellow eyes or skin
Other side effects of Colesevelam
Some side effects of colesevelam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Accidental injury
- back pain
- lack or loss of strength
For Healthcare Professionals
Applies to colesevelam: oral powder for reconstitution, oral tablet.
General
The most frequently reported side effects were constipation, dyspepsia, and nausea.[Ref]
Gastrointestinal
Very common (10% or more): Constipation (up to 11%), flatulence
Common (1% to 10%): Dyspepsia, nausea, vomiting, diarrhea, abdominal pain, abnormal stools, abdominal distension
Uncommon (0.1% to 1%): Dysphagia
Very rare (less than 0.01%): Pancreatitis
Frequency not reported: Intestinal obstruction
Postmarketing reports: Bowel obstruction, esophageal obstruction, fecal impaction, exacerbation of hemorrhoids, pancreatitis[Ref]
Metabolic
Common (1% to 10%): Hypertriglyceridemia, hypoglycemia[Ref]
Cardiovascular
Common (1% to 10%): Hypertension, myocardial infarction, aortic stenosis, bradycardia[Ref]
Respiratory
Common (1% to 10%): Pharyngitis, rhinitis, nasopharyngitis, upper respiratory tract infection[Ref]
Other
Common (1% to 10%): Accidental injury, asthenia, flu syndrome/influenza, fatigue, creatine phosphokinase increased
Uncommon (0.1% to 1%): Serum transaminases increased[Ref]
Musculoskeletal
Common (1% to 10%): Myalgia, back pain[Ref]
Nervous system
Common (1% to 10%): Headache
Postmarketing reports: Increased seizure activity (resulting from decreased phenytoin levels)[Ref]
Hypersensitivity
Frequency not reported: Hypersensitivity reaction[Ref]
In clinical trials of type 2 diabetes, patient who received this drug as an add on to a sulfonylurea discontinued the trial due to body rash and mouth blistering that occurred on the first day of therapy.[Ref]
Hematologic
Postmarketing reports: Reduced international normalized ration (INR) in patient on warfarin therapy
Hepatic
Postmarketing reports: Increased transaminases
Endocrine
Postmarketing reports: Elevated thyroid-stimulating hormone (TSH) in patients receiving thyroid hormone replacement
