Applies to cortisone: oral tablets.

Side effects include:

Associated with long-term therapy: bone loss, cataracts, indigestion, muscle weakness, back pain, bruising, oral candidiasis.

For Healthcare Professionals

Applies to cortisone: compounding powder, injectable suspension, oral tablet.

Cardiovascular

Frequency not reported: Congestive heart failure (in susceptible patients), hypertension, myocardial rupture following recent myocardial infarction, thromboembolism^[Ref]

Gastrointestinal

Frequency not reported: Peptic ulcer with possible perforation and hemorrhage, perforation of the small and large bowel (particularly in inflammatory bowel disease patients), pancreatitis, abdominal distention, ulcerative esophagitis, nausea^[Ref]

Musculoskeletal

Frequency not reported: Muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humoral heads, pathologic fracture of long bones, tendon rupture, growth suppression in children^[Ref]

Psychiatric

Frequency not reported: Psychic disturbances^[Ref]

Nervous system

Frequency not reported: Convulsions, increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment, vertigo, headache^[Ref]

Endocrine

Frequency not reported: Development of cushingoid state, secondary adrenocortical and pituitary unresponsiveness (particularly during stress, e.g. trauma, surgery, illness)^[Ref]

Ocular

Frequency not reported: Posterior subcapsular cataracts, increased intraocular pressure, glaucoma, exophthalmos^[Ref]

Genitourinary

Frequency not reported: Menstrual irregularities^[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity^[Ref]

Metabolic

Frequency not reported: Sodium retention, fluid retention, potassium loss, hypokalemic alkalosis, decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemics (in diabetics), negative nitrogen balance due to protein catabolism, increased appetite^[Ref]

Other

Frequency not reported: Impaired wound healing, suppressed reactions to skin tests, weight gain, malaise^[Ref]

Dermatologic

Frequency not reported: Thin fragile skin, petechiae and ecchymosis, erythema, increased sweating, allergic dermatitis, urticaria, angioneurotic edema, other cutaneous reactions, hirsutism^[Ref]