Note: This document contains side effect information about losartan. Some dosage forms listed on this page may not apply to the brand name Cozaar.
Summary
Common side effects of Cozaar include: asthenia, chest pain, diarrhea, fatigue, and hypoglycemia. Other side effects include: hyperkalemia, hypotension, and orthostatic hypotension. Continue reading for a comprehensive list of adverse effects.
Applies to losartan: oral extemporaneous suspension, oral tablets.
Warning
- May cause fetal and neonatal morbidity and mortality if used during pregnancy.1 2 56 57 (See Fetal/Neonatal Morbidity and Mortality under Cautions.)
- If pregnancy is detected, discontinue as soon as possible.1 2 57
Side effects include:
Patients with hypertension: upper respiratory infection, dizziness, nasal congestion, back pain, leg pain, muscle cramp, sinusitis.
Patients with diabetic nephropathy: Urinary tract infection, diarrhea, anemia, asthenia/fatigue, hypoglycemia, chest pain, cough, bronchitis, diabetic vascular disease, influenza-like disease, cataracts, cellulitis, hyperkalemia, hypotension, muscular weakness, sinusitis, gastritis, hypoesthesia, infection, knee pain, and leg pain.
For Healthcare Professionals
Applies to losartan: oral tablet.
General
The most common adverse reactions were upper respiratory infection and dizziness.[Ref]
Respiratory
Common (1% to 10%): Nasal congestion, upper respiratory infection, sinusitis, pharyngitis, cough, sinus disorder
Uncommon (0.1% to 1%): Dyspnea
Frequency not reported: Bronchitis, pharyngeal discomfort, epistaxis, rhinitis, respiratory congestion[Ref]
Gastrointestinal
Common (1% to 10%): Abdominal pain, nausea, diarrhea, dyspepsia
Uncommon (0.1% to 1%): Obstipation, vomiting
Frequency not reported: Constipation, dental pain, dry mouth, flatulence, gastritis[Ref]
Musculoskeletal
Common (1% to 10%): Muscle cramp, back pain, leg pain, myalgia
Frequency not reported: Arm pain, hip pain, joint swelling, knee pain, musculoskeletal pain, shoulder pain, stiffness, arthralgia, arthritis, fibromyalgia, muscle weakness
Postmarketing reports: Rhabdomyolysis[Ref]
Renal
Common (1% to 10%): Renal impairment, renal failure, BUN increased, serum creatinine increased[Ref]
Nervous system
Common (1% to 10%): Dizziness, headache, vertigo
Uncommon (0.1% to 1%): Somnolence
Rare (less than 0.1%): Paresthesia, syncope, cerebrovascular accident
Frequency not reported: Ataxia, hypesthesia, memory impairment, migraine, peripheral neuropathy, tremor, taste perversion, tinnitus[Ref]
Other
Common (1% to 10%): Asthenia/fatigue, edema/swelling, chest pain
Frequency not reported: Facial edema, fever, orthostatic effects
Postmarketing reports: Malaise[Ref]
Metabolic
Common (1% to 10%): Hyperkalemia, serum potassium increased, hypoglycemia
Frequency not reported: Anorexia, gout
Postmarketing reports: Hyponatremia[Ref]
Cardiovascular
Common (1% to 10%): Orthostatic hypotension
Uncommon (0.1% to 1%): Palpitation, angina pectoris
Rare (less than 0.1%): Atrial fibrillation
Frequency not reported: Second degree atrioventricular block, hypotension, myocardial infarction, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation, flushing
Postmarketing reports: Vasculitis[Ref]
Psychiatric
Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Sleep disorder
Frequency not reported: Anxiety, anxiety disorder, confusion, depression, dream abnormality, libido decreased, nervousness, panic disorder[Ref]
Hematologic
Common (1% to 10%): Anemia
Rare (less than 0.1%): Hemolysis
Postmarketing reports: Thrombocytopenia, hemoglobin decreased, hematocrit decreased[Ref]
Dermatologic
Uncommon (0.1% to 1%): Urticaria, pruritus, rash
Rare (less than 0.1%): Angioedema, superficial peeling of palms
Frequency not reported: Alopecia, dermatitis, dry skin, ecchymosis, erythema, photosensitivity, sweating
Postmarketing reports: Erythroderma[Ref]
Hepatic
Rare (less than 0.1%): ALT increased
Postmarketing reports: Hepatitis, liver enzymes increased, serum bilirubin increased, pancreatitis, liver function abnormalities[Ref]
Genitourinary
Frequency not reported: Impotence, nocturia, urinary frequency, urinary tract infection[Ref]
Ocular
Frequency not reported: Blurred vision, burning/stinging in the eye, conjunctivitis, visual acuity decreased[Ref]
Immunologic
Frequency not reported: Flu-like symptoms
Postmarketing reports: Anaphylactic reactions, hypersensitivity reactions[Ref]
