Note: This document contains side effect information about hydroxocobalamin. Some dosage forms listed on this page may not apply to the brand name Cyanokit.
Applies to hydroxocobalamin: intravenous powder for solution.
Serious side effects of Cyanokit
Along with its needed effects, hydroxocobalamin (the active ingredient contained in Cyanokit) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking hydroxocobalamin:
More common
- Blurred vision
- dizziness
- headache
- nervousness
- pounding in the ears
- redness of the skin
- slow or fast heartbeat
Incidence not known
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- cough
- difficult or labored breathing
- difficulty with swallowing
- feeling of warmth
- hives or welts, itching, or skin rash
- large, hive-like swelling on the , eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- redness of the face, neck, arms, and occasionally, upper chest
- sudden sweating
- tightness in the chest
- tingling of the hands or feet
- unusual tiredness or weakness
- unusual weight gain or loss
Other side effects of Cyanokit
Some side effects of hydroxocobalamin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Blemishes on the skin
- dry, red, hot, or irritated skin
- nausea
- pimples
- red colored urine
Incidence not known
- Acid or sour stomach
- being forgetful
- belching
- diarrhea
- heartburn
- indigestion
- redness or swelling of the eyes
- restlessness
- stomach discomfort, upset, or pain
For Healthcare Professionals
Applies to hydroxocobalamin: compounding powder, injectable solution, intravenous powder for injection.
Cardiovascular
Very common (10% or more): Blood pressure increased (28% with 10 gram dose)
Frequency not reported: Increased blood pressure (particularly diastolic), hot flush, ventricular extrasystoles, electrocardiogram repolarization abnormality, heart rate increased[Ref]
Ventricular extrasystoles, electrocardiogram repolarization abnormality, and heart rate increased were seen in known/suspected cyanide poisoning patients.[Ref]
Gastrointestinal
Very common (10% or more): Nausea (11% with 10 gram dose)
Frequency not reported: Dysphagia, abdominal discomfort, vomiting, diarrhea, dyspepsia, hematochezia[Ref]
Dermatologic
Very common (10% or more): Erythema (100% with 10 gram dose), rash (primarily acneiform) (44% with 10 gram dose)
Frequency not reported: Urticaria, pruritus[Ref]
Genitourinary
Very common (10% or more): Chromaturia (red colored urine) (100% with 5 or 10 gram dose), oxalate crystals in urine (61% with 5 gram dose)
Postmarketing reports: Urine calcium oxalate crystals[Ref]
Hematologic
Very common (10% or more): Lymphocyte count decreased (17% with 10 gram dose)[Ref]
Local
Very common (10% or more): Infusion site reaction (39% with 10 gram dose)[Ref]
Renal
Postmarketing reports: Acute renal failure with acute tubular necrosis, renal impairment[Ref]
Nervous system
Very common (10% or more): Headache (33% with 10 gram dose)
Frequency not reported: Memory impairment, dizziness[Ref]
Respiratory
Frequency not reported: Dyspnea, throat tightness, dry throat, pleural effusion[Ref]
Pleural effusion was seen in known/suspected cyanide poisoning patients.[Ref]
Hypersensitivity
Frequency not reported: Allergic reaction[Ref]
Ocular
Frequency not reported: Swelling, irritation, redness[Ref]
Other
Frequency not reported: Peripheral edema, chest discomfort[Ref]
Psychiatric
Frequency not reported: Restlessness[Ref]
