Note: This document contains side effect information about diphtheria and tetanus toxoids / pertussis, acellular. Some dosage forms listed on this page may not apply to the brand name Daptacel (DTaP).
Applies to diphtheria and tetanus toxoids / pertussis, acellular: intramuscular suspension.
Serious side effects of Daptacel (DTaP)
Along with its needed effects, diphtheria and tetanus toxoids/pertussis, acellular may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking diphtheria and tetanus toxoids / pertussis, acellular:
Less common
- Collapse or shock-like state
- crying for 3 hours or more
- fever over 102.2 °F
- redness or swelling of 4 inches or more at the injection site
- seizures (convulsions)
- severe pain at the injection site
Incidence not known
- Agitation
- back pain
- black, tarry stools
- bleeding gums
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- blood in the urine or stools
- bloody nose
- bluish color of the fingernails, lips, skin, palms, or nail beds
- blurred vision
- confusion
- cough
- diarrhea
- difficulty with swallowing
- dizziness
- drowsiness
- fast heartbeat
- hallucinations
- headache
- hoarseness
- irritability
- irritation
- joint pain, stiffness, or swelling
- loss of bladder control
- loss of consciousness
- loss of strength or energy
- muscle pain or weakness
- nausea and vomiting
- pain or cramping in the abdomen or stomach
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rash with flat lesions or small raised lesions on the skin
- screaming
- shortness of breath
- sleepiness or unusual drowsiness
- sneezing
- sore throat
- stiff neck
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- tightness in the chest
- total body jerking
- unusual bleeding or bruising
- unusual tiredness or weakness (sudden and severe)
Other side effects of Daptacel (DTaP)
Some side effects of diphtheria and tetanus toxoids / pertussis, acellular may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Fever of 99.5 °F or more
- fussiness
- loss of appetite
- mild pain, redness, swelling, or tenderness at the injection site
- restlessness
- weight loss
Incidence not known
- Crying
- ear pain
For Healthcare Professionals
Applies to diphtheria and tetanus toxoids / pertussis, acellular: intramuscular suspension.
Nervous system
Very common (10% or more): Irritability/fussiness (62%), drowsiness (54%), loss of appetite (27%)
Uncommon (0.1% to 1%): Persistent crying (3 or more hours)
Rare (less than 0.1%): Seizures
Postmarketing reports: Encephalopathy, headache, hypotonia, syncope[Ref]
Local
Very common (10% or more): Local redness (39%), local pain (32%), local swelling (25%)
Postmarketing reports: Injection site reaction, injection site induration[Ref]
Other
Very common (10% or more): Fever (100.4F or higher) (30%)
Postmarketing reports: Ear pain, fatigue, Sudden Infant Death Syndrome[Ref]
Hypersensitivity
Postmarketing reports: Anaphylactic reaction, hypersensitivity[Ref]
Hematologic
Postmarketing reports: Lymphadenopathy, thrombocytopenia[Ref]
Immunologic
Postmarketing reports: Bronchitis, cellulitis, respiratory tract infection[Ref]
Cardiovascular
Postmarketing reports: Cyanosis[Ref]
Dermatologic
Postmarketing reports: Angioedema, erythema, pruritus, rash, urticaria[Ref]
Respiratory
Postmarketing reports: Apnea, cough[Ref]
